A mechanism of the glycogenolytic action of bacterial endotoxin.
These experiments have demonstrated that liver glycogen may rise or fall after endotoxin administration, depending upon the antecedent diet and that total adrenalectomy followed by corticosteroid replacement abolishes the glycogenolytic effect of sublethal doses of endotoxin. It is concluded that the derangements of carbohydrate metabolism observed following the administration of sublethal quantities of bacterial endotoxin represent, not a direct hepatotoxic effect of endotoxin, but rather the passive consequence of epinephrine release.
17 references, click to expand
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The role of epinephrine in the reactions produced by the endotoxins of gram-negative bacteria. I. Hemorrhagic necrosis produced by epinephrine in the skin of endotoxin-treated rabbits.J Exp Med. 1956 Dec 1;104(6):865-80 PMID: 13376809
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Some metabolic aspects of host-parasite interaction using the albino mouse and Salmonella typhimurium.J Infect Dis. 1954 Nov-Dec;95(3):246-59 PMID: 13212124
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Glycogen reduction in chick liver during pullorum disease.J Bacteriol. 1958 Aug;76(2):225 PMID: 13563421
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Mechanism of inhibition of glycogen synthesis by endotoxins of Salmonella aertrycke and type I meningococcus.Proc Soc Exp Biol Med. 1949 Jul;71(3):362-4 PMID: 18136481
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Physiological approach to successful treatment of endotoxin shock in the experimental animal.AMA Arch Surg. 1959 Mar;78(3):464-71 PMID: 13626356
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Effect of bacterial endotoxin on carbohydrate metabolism of animals.J Bacteriol. 1959 Jun;77(6):811 PMID: 13664667
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The elimination of metabolic disturbances produced by the injection of S. typhi, S. paratyphi B, Sh. Flexneri and prevention of animals from death through the application of adenosinetriphosphate.Jpn J Exp Med. 1955 Jun;25(3):133-41 PMID: 13318778
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Studies on the mechanism of chlorpromazine protection against Brucella endotoxin in mice.J Lab Clin Med. 1957 May;49(5):708-15 PMID: 13416729
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Effect of chlorpromazine and dibenzyline on bacterial toxins.Proc Soc Exp Biol Med. 1956 Jul;92(3):617-21 PMID: 13359484
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The intestinal factor in irreversible endotoxin shock.Ann Surg. 1958 Oct;148(4):513-24; discussion 524-5 PMID: 13583926
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The vasoconstriction caused by a pyrogen.J Physiol. 1957 Oct 30;138(3):417-33 PMID: 13481882
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The differential response of the adrenal cortex and medulla to bacterial endotoxin.J Clin Invest. 1959 Jul;38(7):1120-5 PMID: 13664787
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The detection of bacterial endotoxins in the plasma of dogs with experimental peritonitis.Ann Surg. 1956 Jul;144(1):51-6 PMID: 13327841
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Effect of endotoxin on gastrointestinal mucosa of the rat.Proc Soc Exp Biol Med. 1959 Mar;100(3):557-61 PMID: 13634207
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Increase of Adrenal Secretion in Fever.Proc Natl Acad Sci U S A. 1924 Jun;10(6):247-8 PMID: 16586935
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The enhancement of infection during shock produced by bacterial toxins and other agents.Br J Exp Pathol. 1950 Feb;31(1):73-95 PMID: 15420347
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The physiological disturbances produced by endotoxins.Annu Rev Physiol. 1954;16:467-90 PMID: 13171836
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