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PMID: 13779027 Published · ppublish English Journal Article

Antibody formation. I. The suppression of antibody formation by passively administered antibody.

The Journal of experimental medicine ·Vol. 113 ·1961-05-01 ·Pages 935-57

UHR JW, BAUMANN JB

Abstract

The suppression of antibody formation by passively administered antibody is influenced by the dose and nature of the antigen, type of immunization procedure, ratio of antibody to antigen, species origin and characteristics of the antiserum used, as well as the species selected for immunization. In guinea pigs, diphtheria antitoxin formation can be effectively suppressed by an intravenous injection of excess homologous or heterologous antitoxin as long as 5 days after toxoid immunization and after delayed-type hypersensitivity to toxoid has developed. Following the period of antibody suppression which lasts 2 to 7 weeks, serum antibody can usually be demonstrated. It is proposed that this delayed immunization results from dissociation of antigen, since diphtheritic paralysis and death can be produced in guinea pigs and rabbits by the intravenous injection of toxin-antitoxin precipitates formed in antitoxin excess. This syndrome is prevented by injection of excess horse antitoxin 1 hour after injection of the toxin-antitoxin complexes.

Keywords
ANTIBODIES
MeSH Terms
Animals Antibodies Antibody Formation Diphtheria Diphtheria Antitoxin Guinea Pigs Horses Immunization Rabbits
Chemicals
Antibodies Diphtheria Antitoxin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
UHR J W
BAUMANN J B
References (23)
23 references, click to expand
  1. DEPRESSION BY ANTIBODY OF THE IMMUNE RESPONSE TO HOMOGRAFTS AND ITS ROLE IN IMMUNOLOGICAL ENHANCEMENT.
    J Exp Med. 1960 Aug 1;112(2):293-314 PMID: 19867173
  2. Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction.
    Prog Allergy. 1958;5:459-508 PMID: 13579002
  3. The elimination of heterologous serum proteins and associated antibody responses in guinea pigs and rats.
    J Immunol. 1957 Jul;79(1):24-33 PMID: 13475804
  4. Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes.
    J Exp Med. 1957 Jan 1;105(1):11-24 PMID: 13385403
  5. Biologic reactivity of antigen and antibody in specific precipitate.
    Proc Soc Exp Biol Med. 1959 Mar;100(3):649-51 PMID: 13634241
  6. Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.
    J Exp Med. 1960 Jul 1;112:107-24 PMID: 13731716
  7. Combined immunization against diphtheria, tetanus and pertussis in newborn infants, duration of antibody levels; antibody titers after booster dose; effect of passive immunity to diphtheria on active immunization with diphtheria toxoid.
    Pediatrics. 1949 Feb;3(2):181-94 PMID: 18111425
  8. The effect of prior injections of tissue antiserums on the survival of cancer homoiografts in mice.
    Cancer Res. 1952 Feb;12(2):110-2 PMID: 14896404
  9. THE DISPLACEMENT OF TOXIN FROM NEUTRALIZED TOXIN-ANTITOXIN MIXTURES BY "TOXOID" OR ANATOXIN.
    Science. 1930 May 16;71(1846):511-2 PMID: 17778756
  10. The effect of whole body x radiation on the specific anamnestic response in the rabbit.
    J Infect Dis. 1956 Nov-Dec;99(3):246-52 PMID: 13376922
  11. Elimination of antigen-antibody complexes from sera of rabbits.
    J Immunol. 1958 Sep;81(3):204-13 PMID: 13575816
  12. [Experimental sero-anatoxin therapy of tetanus].
    Schweiz Z Pathol Bakteriol. 1951;14(5):554-9 PMID: 14921830
  13. Antibody formation. II. The specific anamnestic antibody response.
    J Exp Med. 1961 May 1;113:959-70 PMID: 13779028
  14. ACTIVE IMMUNITY PRODUCED BY SO CALLED BALANCED OR NEUTRAL MIXTURES OF DIPHTHERIA TOXIN AND ANTITOXIN.
    J Exp Med. 1909 Mar 1;11(2):241-56 PMID: 19867246
  15. ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS.
    J Exp Med. 1932 Sep 30;56(4):493-505 PMID: 19870081
  16. [A micro-method of immuno-electrophoresis].
    Int Arch Allergy Appl Immunol. 1955;7(2):103-10 PMID: 13262900
  17. [The effect of specific inhibition in biosynthesis of tryptophan-desmase by Aerobacter aerogenes].
    C R Hebd Seances Acad Sci. 1953 Feb 2;236(5):530-2 PMID: 13033387
  18. A quantitative study of a technique of double diffusion in agar.
    J Immunol. 1956 Jul;77(1):52-60 PMID: 13346095
  19. Studies of the immunology of the newborn infant. II. Interference with active immunization by passive transplacental circulating antibody.
    Pediatrics. 1952 Sep;10(3):328-34 PMID: 12993541
  20. STUDIES ON THE MOLECULAR WEIGHT OF DIPHTHERIA TOXIN, ANTITOXIN, AND THEIR REACTION PRODUCTS.
    J Exp Med. 1940 Jan 31;71(2):247-62 PMID: 19870960
  21. Use of ultraviolet absorption spectroscopy in the quantitative precipitin reaction.
    J Immunol. 1949 Aug;62(4):437-51 PMID: 18133627
  22. The active immunization of guinea-pigs passively immunized with homologous antitoxic serum.
    J Hyg (Lond). 1955 Jun;53(2):172-9 PMID: 14392315
  23. IMMUNITY FOLLOWING THE INJECTION OF MONKEYS WITH MIXTURES OF POLIOMYELITIS VIRUS AND CONVALESCENT HUMAN SERUM.
    J Exp Med. 1931 Jan 1;53(1):115-21 PMID: 19869821
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.113.5.935
Published
1961-05-01
Pages
935-57
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2137415
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.113.5.935 PMC Full Text View journal details
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