Abstract
Despite the fact that the early components of the mouse and human complement cascades are very similar, there are marked differences between the two species in the structure of C3 receptors and the molecules that control homologous lysis. Here, Michael Holers, Taroh Kinoshita and Hector Molina compare and contrast the mouse and human RCA region products and conclude that the receptor and regulatory roles are conserved despite the structural variation.
MeSH Terms
Animals
Antigens, CD/genetics,metabolism
Antigens, Differentiation, B-Lymphocyte/genetics,metabolism
Biological Evolution
CD55 Antigens
Complement Activation
Complement C3/metabolism
Consensus Sequence
Humans
Macrophage-1 Antigen/genetics,metabolism
Membrane Cofactor Protein
Membrane Glycoproteins/genetics,metabolism
Membrane Proteins/genetics,metabolism
Mice/genetics,immunology
Models, Biological
Multigene Family
Protein Conformation
Receptors, Complement/genetics,metabolism
Receptors, Complement 3b
Receptors, Complement 3d
Recombinant Fusion Proteins/metabolism
Repetitive Sequences, Nucleic Acid
Species Specificity
Chemicals
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
CD46 protein, human
CD55 Antigens
Complement C3
Macrophage-1 Antigen
Mcp protein, mouse
Membrane Cofactor Protein
Membrane Glycoproteins
Membrane Proteins
Receptors, Complement
Receptors, Complement 3b
Receptors, Complement 3d
Recombinant Fusion Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Holers V M
Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110.
Kinoshita T
Molina H