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PMID: 1378280 Published · ppublish English Comparative Study Journal Article Review

The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function.

Immunology today ·Vol. 13 ·No. 6 ·1992-06-00 ·Pages 231-6

Holers VM, Kinoshita T, Molina H

Abstract

Despite the fact that the early components of the mouse and human complement cascades are very similar, there are marked differences between the two species in the structure of C3 receptors and the molecules that control homologous lysis. Here, Michael Holers, Taroh Kinoshita and Hector Molina compare and contrast the mouse and human RCA region products and conclude that the receptor and regulatory roles are conserved despite the structural variation.

Related Genes
MeSH Terms
Animals Antigens, CD/genetics,metabolism Antigens, Differentiation, B-Lymphocyte/genetics,metabolism Biological Evolution CD55 Antigens Complement Activation Complement C3/metabolism Consensus Sequence Humans Macrophage-1 Antigen/genetics,metabolism Membrane Cofactor Protein Membrane Glycoproteins/genetics,metabolism Membrane Proteins/genetics,metabolism Mice/genetics,immunology Models, Biological Multigene Family Protein Conformation Receptors, Complement/genetics,metabolism Receptors, Complement 3b Receptors, Complement 3d Recombinant Fusion Proteins/metabolism Repetitive Sequences, Nucleic Acid Species Specificity
Chemicals
Antigens, CD Antigens, Differentiation, B-Lymphocyte CD46 protein, human CD55 Antigens Complement C3 Macrophage-1 Antigen Mcp protein, mouse Membrane Cofactor Protein Membrane Glycoproteins Membrane Proteins Receptors, Complement Receptors, Complement 3b Receptors, Complement 3d Recombinant Fusion Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Holers V M
Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110.
Kinoshita T
Molina H
Article Info
Journal
Immunology today
Abbr.
Immunol Today
ISSN
0167-5699
Published
1992-06-00
Pages
231-6
Language
English
Region
England
NLM ID
8008346
Subset
IM
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