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PMID: 1379514 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cyclin D1 messenger RNA is inducible by platelet-derived growth factor in cultured fibroblasts.

Cancer research ·Vol. 52 ·No. 16 ·1992-08-15 ·Pages 4522-5

Surmacz E, Reiss K, Sell C, Baserga R

Abstract

In fibroblasts in culture, the levels of cyclin D1 mRNA are growth regulated. In mouse and in human fibroblasts, both serum and platelet-derived growth factor increase cyclin D1 mRNA levels with similar kinetics of induction. Insulin-like growth factor 1 by itself does not induce cyclin D1 expression, and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does not affect the growth-regulated levels of cyclin D1 mRNA.

MeSH Terms

3T3 Cells/metabolism Animals Base Sequence Carrier Proteins/genetics,pharmacology Cyclins/biosynthesis Fibroblasts/metabolism Humans Insulin-Like Growth Factor Binding Protein 1 Leukemia, Promyelocytic, Acute/genetics,metabolism Mice Molecular Sequence Data Platelet-Derived Growth Factor/pharmacology Polymerase Chain Reaction/methods RNA, Messenger/biosynthesis Resting Phase, Cell Cycle Tumor Cells, Cultured

Chemicals

Carrier Proteins Cyclins Insulin-Like Growth Factor Binding Protein 1 Platelet-Derived Growth Factor RNA, Messenger

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Surmacz E

Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541.

Reiss K

Sell C

Baserga R

Article Info

Journal

Cancer research

Abbr.

Cancer Res

ISSN

0008-5472

Published

1992-08-15

Pages

4522-5

Language

English

Region

United States

NLM ID

2984705R

Subset

Grants

NCI NIH HHS · CA53484 · United States

NIGMS NIH HHS · GM 33694 · United States

External Links

PubMed source View journal details

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Cyclin D1 messenger RNA is inducible by platelet-derived growth factor in cultured fibroblasts.

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