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PMID: 13803718 Published · ppublish English Journal Article

A comparative study of the effects of drugs on the arousal system of the brain.

British journal of pharmacology and chemotherapy ·Vol. 14 ·1959-09-00 ·Pages 340-9

BRADLEY PB, KEY BJ

Abstract

The effects of twelve drugs, eleven of which are reported to be tranquillizers, have been studied in relation to thresholds for arousal produced both by direct stimulation of the brain stem reticular formation and also by afferent nerve stimulation. The drugs can be grouped according to whether (a) like chlorpromazine they produce a slight rise in thresholds for brain stem stimulation and block sensory-induced arousal, (b) cause dissociation between behaviour and electrical activity of the brain, (c) have no effects on thresholds for brain stem stimulation and only slight effects on afferent nerve-induced arousal or (d) have no effect on arousal responses at all.

Keywords
BRAIN/pharmacology TRANQUILIZING AGENTS/pharmacology
MeSH Terms
Arousal Brain/pharmacology Brain Stem Chlorpromazine Reticular Formation Tranquilizing Agents/pharmacology
Chemicals
Tranquilizing Agents Chlorpromazine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
BRADLEY P B
KEY B J
References (18)
18 references, click to expand
  1. [Effects of chloropromazine on central nervous system].
    Sem Hop. 1954 Jun 6;30(37):2346-53 PMID: 13178726
  2. [New series of neuroplegic compounds derived from phenothiazine].
    C R Hebd Seances Acad Sci. 1957 Jan 7;244(2):255-8 PMID: 13414166
  3. The pharmacological properties of 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (miltown), a new interneuronal blocking agent.
    J Pharmacol Exp Ther. 1954 Dec;112(4):413-23 PMID: 13222235
  4. Evidence for the participation of serotonin in mental processes.
    Ann N Y Acad Sci. 1957 Mar 14;66(3):649-65; discussion, 665-7 PMID: 13425248
  5. The treatment of depressive conditions with imipramine (G 22355).
    Can Psychiatr Assoc J. 1958 Oct;3(4):155-64 PMID: 13596934
  6. Neuropharmacological aspects of reserpine.
    Ann N Y Acad Sci. 1955 Apr 15;61(1):17-26 PMID: 14377269
  7. The use of frenquel in the treatment of disturbed patients with psychoses of long duration.
    Am J Psychiatry. 1955 Nov;112(5):343-8 PMID: 13268712
  8. The effect of chlorpromazine and methopromazine on the electrical activity of the brain in the cat.
    Electroencephalogr Clin Neurophysiol. 1957 May;9(2):191-215 PMID: 13414644
  9. Effects of hallucinogenic and tranquilizing drugs on serotonin evoked uterine contractions.
    Proc Soc Exp Biol Med. 1956 Jan;91(1):39-41 PMID: 13297703
  10. [Electroencephalographic study of the central action of largactil (4560 RP)].
    Rass Neurol Veg. 1952 Apr;9(4-5):211-5 PMID: 13047616
  11. [Sympathetic tonus and cortical electrical activity].
    Electroencephalogr Clin Neurophysiol. 1954 Feb;6(1):119-44 PMID: 13141926
  12. Serotonin-releasing activity limited to Rauwolfia alkaloids with tranquilizing action.
    Science. 1956 Jun 1;123(3205):992-3 PMID: 13324134
  13. A technique for recording the electrical activity of the brain in the conscious animal.
    Electroencephalogr Clin Neurophysiol. 1953 Aug;5(3):451-6 PMID: 13068313
  14. Corticifugal influences on intrinsic brainstem conduction in cat and monkey.
    J Neurophysiol. 1957 Jan;20(1):1-16 PMID: 13398848
  15. Action of nicotine and of the "ganglioplegiques centraux" on the electrical activity of the brain.
    J Pharmacol Exp Ther. 1954 Jul;111(3):349-59 PMID: 13175115
  16. [Pharmacodynamic properties of 3-chloro-10-(3-dimethylaminopropyl)-phenothiazine hydrochloride (R.P. 4560); experimental study of a new substance used in potentialized anesthesia and in artificial hibernation].
    Arch Int Pharmacodyn Ther. 1953 Jan;92(3-4):305-61 PMID: 13041303
  17. Projections from cortex to cephalic brain stem (reticular formation) in monkey.
    J Neurophysiol. 1955 Jan;18(1):74-95 PMID: 13222159
  18. Effect of drugs on conditioning and habituation to arousal stimuli in animals.
    Nature. 1958 Nov 29;182(4648):1517-9 PMID: 13613324
Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1959.tb00254.x
Published
1959-09-00
Pages
340-9
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1481747
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1959.tb00254.x PMC Full Text
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