The fate of oxytocin in male and female rats.

British journal of pharmacology and chemotherapy ·Vol. 14 ·1959-09-00 ·Pages 327-33

GINSBURG M, SMITH MW

Abstract

A method for quantitative extraction of oxytocin from blood is described. The disappearance of injected oxytocin from the circulation in rats was shown to depend upon its uptake in the kidneys and in organs of the splanchnic vascular area. In lactating rats there was uptake by an additional organ or tissue, probably the mammary gland. In animals without kidneys or lactating mammary glands and with no circulation in the splanchnic area oxytocin was distributed into a volume greater than the extracellular fluid volume, and after equilibration the concentration in plasma did not change significantly. During severe haemorrhage increased amounts of antidiuretic activity were detected in blood when there was no significant increase in oxytocic activity.

Keywords

OXYTOCIN/metabolism

MeSH Terms

Animals Female Humans Lactation Male Oxytocin/metabolism Rats

Chemicals

Oxytocin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

GINSBURG M

SMITH M W

References (15)

15 references, click to expand

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Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1959.tb00252.x

Published

1959-09-00

Pages

327-33

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1481739

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1959.tb00252.x PMC Full Text

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The fate of oxytocin in male and female rats.

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