Increased incidence of non-tasters of phenylthiocarbamide among congenital athyreotic cretins.

Science (New York, N.Y.) ·Vol. 131 ·No. 3404 ·1960-03-25 ·Pages 929

SHEPARD TH, GARTLER SM

Abstract

The incidence of nontasters for phenylthiocarbamide was found to be significantly higher in 27 athyreotic cretins than in normal adults and children. A significant increase of nontasters among the parents and siblings of these cretins was also found. These findings are discussed in relation to maldevelopment of the fetal thyroid in nontaster genotypes.

Keywords

CRETINISM/physiology TASTE/genetics THIOUREA/related compounds

MeSH Terms

Adult Child Congenital Hypothyroidism/physiology Female Humans Incidence Phenylthiourea Taste/genetics Thiourea/analogs & derivatives

Chemicals

Phenylthiourea Thiourea

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

SHEPARD T H

GARTLER S M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.131.3404.929

Published

1960-03-25

Pages

929

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.131.3404.929 View journal details

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Increased incidence of non-tasters of phenylthiocarbamide among congenital athyreotic cretins.

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