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PMID: 13859099 Published · ppublish English Journal Article

The induction of a rheumatoid factor-like substance in rabbits.

The Journal of experimental medicine ·Vol. 114 ·1961-11-01 ·Pages 791-806

ABRUZZO JL, CHRISTIAN CL

Abstract

Hyperimmunization of two groups of rabbits with killed Escherichia coli and Bacillus subtilis has resulted in the formation of a serum factor (RFLS) which resembled the human rheumatoid factor. It was a heat-stable protein that migrated electrophoretically in the gamma-beta globulin range and sedimented rapidly with ultracentrifugation. The serologic properties of the RFLS were destroyed by mercaptoethanol. It reacted primarily with rabbit gamma globulin in an aggregated state (immune complexes or physically aggregated gamma globulin) and demonstrated cross-reactivity with human gamma globulin.

Keywords
ANTIGEN-ANTIBODY REACTIONS/experimental
MeSH Terms
Animals Antigen-Antibody Reactions Bacillus subtilis Humans Immunization Rabbits Rheumatoid Factor gamma-Globulins
Chemicals
gamma-Globulins Rheumatoid Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
ABRUZZO J L
CHRISTIAN C L
References (26)
26 references, click to expand
  1. Collagen disease in patients with congenital agammaglobulinemia.
    Trans Assoc Am Physicians. 1956;69:93-7 PMID: 13380950
  2. The simultaneous occurrence of rheumatoid arthritis and agammaglobulinemia.
    J Lab Clin Med. 1957 Mar;49(3):343-57 PMID: 13406366
  3. Dissociation of human serum macroglobulins.
    Science. 1957 Mar 29;125(3248):600-1 PMID: 13409017
  4. Antigenicity of antibodies of the same species.
    Nature. 1957 Jun 29;179(4574):1351-2 PMID: 13451620
  5. Relation of high molecular weight proteins to the serological reactions in rheumatoid arthritis.
    Ann Rheum Dis. 1957 Sep;16(3):315-21 PMID: 13470733
  6. Genetic studies on rheumatoid arthritis.
    Ann Rheum Dis. 1958 Jun;17(2):160-8 PMID: 13559935
  7. Observations concerning positive serologic reactions for rheumatoid factor in certain patients with sarcoidosis and other hyperglobulinemic states.
    Arthritis Rheum. 1958 Aug;1(4):289-96 PMID: 13560342
  8. Differences in the antigenic components of sera of individual rabbits as shown by induced isoprecipitins.
    J Immunol. 1958 Aug;81(2):142-9 PMID: 13563892
  9. Familial occurrence of the rheumatoid factor.
    Arthritis Rheum. 1958 Oct;1(5):392-9 PMID: 13584230
  10. [Presence of antiglobulin factors in anti-bacteria immune serums similar to those in rheumatoid arthritis].
    Ann Inst Pasteur (Paris). 1959 Mar;96(3):295-302 PMID: 13627598
  11. Two antigenically different gamma-globulins in domestic rabbits revealed by isoprecipitins.
    Science. 1959 Apr 17;129(3355):1023-5 PMID: 13646636
  12. Chromatographic studies of the rheumatoid factor.
    J Exp Med. 1959 Aug 1;110(2):169-86 PMID: 13673133
  13. Isolation of rheumatoid factors.
    Arthritis Rheum. 1961 Apr;4:153-60 PMID: 13712879
  14. The F-II agglutinating factors in serums of patients with non-rheumatic diseases.
    Am J Med. 1960 Oct;29:662-71 PMID: 13716262
  15. Isolation of a thermolabile serum protein which precipitates gamma-globulin aggregates and participates in immune hemolysis.
    Proc Soc Exp Biol Med. 1961 Feb;106:291-5 PMID: 13726743
  16. Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.
    J Exp Med. 1960 Jul 1;112:107-24 PMID: 13731716
  17. Precipitating factor for aggregated gamma-globulins in normal human sera.
    Nature. 1961 Jan 21;189:239-40 PMID: 13775280
  18. Studies on the rheumatoid and related serum factors. I. Autoimmunization of rabbits with gamma globulin.
    JAMA. 1960 Sep 3;174:56-63 PMID: 14422384
  19. QUANTITATIVE MICRO-ESTIMATION OF ANTIBODIES IN THE SERA OF MAN AND OTHER ANIMALS.
    Science. 1943 Apr 30;97(2522):405-6 PMID: 17832515
  20. The conglutination phenomenon. IX. The production of immuno-conglutinin in rabbits.
    J Hyg (Lond). 1953 Dec;51(4):509-31 PMID: 13118153
  21. The hemagglutination test for rheumatoid arthritis. II. The influence of human plasma fraction II (gamma globulin) on the reaction.
    J Immunol. 1954 Jan;72(1):66-78 PMID: 13118193
  22. Zone electrophoresis.
    Methods Biochem Anal. 1954;1:141-70 PMID: 13193528
  23. Antibody formation after injection of heterologous immune globulin.
    J Immunol. 1956 Mar;76(3):217-27 PMID: 13306957
  24. [The allotype of certain blood protein antigens].
    C R Hebd Seances Acad Sci. 1956 May 23;242(21):2606-8 PMID: 13343562
  25. Behavior of the rheumatoid arthritis agglutinating factor with immune precipitates.
    J Immunol. 1956 Sep;77(3):181-8 PMID: 13367416
  26. The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis.
    Am J Med. 1956 Dec;21(6):888-92 PMID: 13372565
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.114.5.791
Published
1961-11-01
Pages
791-806
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180373
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.114.5.791 PMC Full Text View journal details
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