Type 1 (insulin-dependent) diabetes mellitus and nitric oxide.

Diabetologia ·Vol. 35 ·No. 8 ·1992-08-00 ·Pages 796-7

Kolb H, Kolb-Bachofen V

Abstract

暂无摘要

MeSH Terms

Animals Cell Death Diabetes Mellitus, Experimental/prevention & control Diabetes Mellitus, Type 1/pathology,prevention & control Free Radicals Humans Islets of Langerhans/pathology Niacinamide/therapeutic use Nitric Oxide/metabolism

Chemicals

Free Radicals Niacinamide Nitric Oxide

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kolb H

Diabetes Research Institute, University of Düsseldorf, FRG.

Kolb-Bachofen V

References (14)

14 references, click to expand

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation.
Biochem Biophys Res Commun. 1991 Mar 29;175(3):752-8 PMID: 2025250
Mechanisms of pancreatic beta-cell destruction in type I diabetes.
Diabetes Care. 1988 Nov-Dec;11 Suppl 1:16-23 PMID: 3069387
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides.
Science. 1992 Feb 7;255(5045):721-3 PMID: 1371193
Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.
Proc Natl Acad Sci U S A. 1990 Dec;87(24):10043-7 PMID: 1702214
Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase.
Endocrinology. 1991 Dec;129(6):3167-73 PMID: 1720090
Cytotoxic action of IL-1 beta against pancreatic islets is mediated via nitric oxide formation and is inhibited by NG-monomethyl-L-arginine.
FEBS Lett. 1992 Mar 24;299(1):103-6 PMID: 1544467
Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice.
Diabetes. 1982 Sep;31(9):749-53 PMID: 6219022
Essential contribution of macrophages to islet cell destruction in vivo and in vitro.
J Autoimmun. 1990 Apr;3 Suppl 1:117-20 PMID: 2140261
Interleukin-1 beta induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets.
Biochem Biophys Res Commun. 1992 Jan 15;182(1):333-40 PMID: 1731791
Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice.
Biochem Biophys Res Commun. 1991 Aug 15;178(3):913-20 PMID: 1831356
Nitric oxide: physiology, pathophysiology, and pharmacology.
Pharmacol Rev. 1991 Jun;43(2):109-42 PMID: 1852778
Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.
J Biol Chem. 1991 Nov 15;266(32):21351-4 PMID: 1657959
Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism.
FEBS Lett. 1990 Dec 10;276(1-2):42-4 PMID: 2265709
Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor.
Life Sci. 1991;49(25):PL213-7 PMID: 1720858

Article Info

Journal

Diabetologia

Abbr.

Diabetologia

ISSN

0012-186X

DOI

10.1007/BF00429103

Published

1992-08-00

Pages

796-7

Language

English

Region

Germany

NLM ID

0006777

Subset

Corrections

CommentIn

PMID: 7686111

External Links

PubMed source DOI: 10.1007/BF00429103 View journal details

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Type 1 (insulin-dependent) diabetes mellitus and nitric oxide.

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