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PMID: 13882768 Published · ppublish English Journal Article

Pharmacological studies upon neurones of the lateral geniculate nucleus of the cat.

British journal of pharmacology and chemotherapy ·Vol. 18 ·1962-04-00 ·Pages 217-46

CURTIS DR, DAVIS R

Abstract

Indoles related to 5-hydroxytryptamine, lysergic acid derivatives, phenethylamine derivatives and some other compounds have been applied electrophoretically to the neurones of the lateral geniculate nucleus of the cat anaesthetized with pentobarbitone sodium. Many of these compounds, particularly 4-, 5- and 7-hydroxytryptamine and ergometrine, depress the orthodromic excitation of the neurones by volleys in optic nerve fibres, but do not affect antidromic excitation by volleys in the optic radiation or chemical excitation by L-glutamic acid. It is concluded that the active depressants either block the access of the excitatory transmitter to subsynaptic receptors or prevent the release of the transmitter from optic nerve terminals. The structure-activity relationships of the depressant substances are discussed.

Keywords
LYSERGIC ACID DIETHYLAMIDE/pharmacology NEURONS/pharmacology PHENYLETHYLAMINES/pharmacology SEROTONIN/pharmacology THALAMUS/pharmacology
MeSH Terms
Animals Cats Geniculate Bodies Glutamic Acid Lysergic Acid Diethylamide/pharmacology Neurons/pharmacology Phenethylamines/pharmacology Serotonin/pharmacology Structure-Activity Relationship Thalamus/pharmacology
Chemicals
Phenethylamines Serotonin Glutamic Acid Lysergic Acid Diethylamide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
CURTIS D R
DAVIS R
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Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1962.tb01404.x
Published
1962-04-00
Pages
217-46
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1482133
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1962.tb01404.x PMC Full Text
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