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PMID: 13884063 Published · ppublish English Journal Article

Effect of guanethidine in revealing cholinergic sympathetic fibres.

British journal of pharmacology and chemotherapy ·Vol. 17 ·1961-10-00 ·Pages 245-60

DAY MD, RAND MJ

Abstract

Guanethidine abolished the inhibitory response of segments of rabbit intestine to stimulation of the sympathetic nerves which accompany the mesenteric arteries. In the majority of experiments a motor response of the intestinal segment was then revealed; it was more readily observed in intestinal segments from young than from adult rabbits. The motor response of the intestine to sympathetic stimulation after guanethidine was blocked by atropine. It was not blocked by hexamethonium and was present in rabbits in which the vagal innervation to the small intestine had been sectioned. In the cat isolated atria, guanethidine blocked the accelerator response to sympathetic nerve stimulation and revealed a response resembling that to stimulation of the vagus. It was concluded that guanethidine blocked the release of noradrenaline and thus revealed the response to the direct action of acetylcholine released from cholinergic sympathetic nerves.

Keywords
AMIDINES/pharmacology SYMPATHETIC NERVOUS SYSTEM/pharmacology
MeSH Terms
Acetylcholine Adrenergic Fibers Amidines/pharmacology Animals Atropine Cats Cholinergic Agents Guanethidine Hexamethonium Norepinephrine Rabbits Sympathetic Nervous System/pharmacology
Chemicals
Amidines Cholinergic Agents Hexamethonium Atropine Acetylcholine Norepinephrine Guanethidine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
DAY M D
RAND M J
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23 references, click to expand
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Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1961.tb01285.x
Published
1961-10-00
Pages
245-60
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1482045
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1961.tb01285.x PMC Full Text
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