Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil).

Experientia ·Vol. 17 ·1961-09-15 ·Pages 417-8

GILLETTE JR, DINGELL JV, SULSER F, KUNTZMAN R, BRODIE BB

Abstract

暂无摘要

Keywords

BRAIN/metabolism IMIPRAMINE/pharmacology

MeSH Terms

Animals Antidepressive Agents Brain/metabolism Desipramine Imipramine/pharmacology Neurochemistry Rats

Chemicals

Antidepressive Agents Imipramine Desipramine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

GILLETTE J R

DINGELL J V

SULSER F

KUNTZMAN R

BRODIE B B

References (4)

4 references, click to expand

[Treatment of depressive states with an iminodibenzyl derivative (G 22355)].
Schweiz Med Wochenschr. 1957 Aug 31;87(35-36):1135-40 PMID: 13467194
On the mechanism of antidepressant action of imipraminelike drugs.
Ann N Y Acad Sci. 1962 Jan 13;96:279-88 PMID: 13918341
[Paper chromatographic determination of metabolic products of tofranil].
Med Esp. 1959;1:381-5 PMID: 14401353
[Metabolism of the psychopharmacological agent tofranil].
Arch Int Pharmacodyn Ther. 1960 Jul 1;126:454-69 PMID: 14401354

Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

Published

1961-09-15

Pages

417-8

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

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