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PMID: 13947582 Published · ppublish English Journal Article

Origin and biologic individuality of the genetic dictionary.

Science (New York, N.Y.) ·Vol. 138 ·No. 3547 ·1962-12-21 ·Pages 1328-31

GIACOMONI D, SPIEGELMAN S

Abstract

Deoxyribonucleic acid contains sequences complementary to homologous amino-acid transfer ribonucleic acid molecules which serve as the translating device between polyribonucleotides and proteins. This implies that the RNA molecules have their primary origin in DNA. From the amount of DNA participating, one would infer that more than 20 complementary sequences exist per genome, a conclusion consistent with a degenerate code. The fact that complex formation occurs most readily with homologous RNA suggests that, while the language remains universal, each dictionary is uniquely identifiable with its own genome.

Keywords
DNA BACTERIAL ESCHERICHIA COLI RNA
MeSH Terms
Amino Acids Base Sequence Biological Products DNA DNA, Bacterial Escherichia coli Individuality RNA RNA, Bacterial RNA, Transfer
Chemicals
Amino Acids Biological Products DNA, Bacterial RNA, Bacterial RNA DNA RNA, Transfer
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
GIACOMONI D
SPIEGELMAN S
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1962-12-21
Pages
1328-31
Language
English
Region
United States
NLM ID
0404511
Subset
OM
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