Experimental glomerulonephritis. II. Immunologic events in the pathogenesis of nephrotoxic serum nephritis in the rat.

The Journal of experimental medicine ·Vol. 117 ·1963-06-01 ·Pages 1019-34

HAMMER DK, DIXON FJ

Abstract

The primary phase of nephrotoxic serum nephritis produced by rabbit nephrotoxic serum appears to be dependent to a great extent, but not completely, upon the participation of serum complement. On the other hand, duck nephrotoxic serum produces its primary renal injury without detectable utilization of or dependence upon serum complement. The secondary phase of nephrotoxic serum nephritis appears to be largely or entirely dependent upon the host's antibody response to the heterologous gamma globulin fixed in the glomeruli. No evidence could be obtained for the existence of an autoimmune antikidney response by the host in this experimental model.

Keywords

GLOMERULONEPHRITIS

MeSH Terms

Animals Antibodies Complement System Proteins Glomerulonephritis Immunoglobulins Kidney Kidney Glomerulus Nephritis Rabbits Rats

Chemicals

Antibodies Immunoglobulins Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

HAMMER D K

DIXON F J

References (26)

26 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.117.6.1019

Published

1963-06-01

Pages

1019-34

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2137595

Subset

External Links

PubMed source DOI: 10.1084/jem.117.6.1019 PMC Full Text View journal details

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Experimental glomerulonephritis. II. Immunologic events in the pathogenesis of nephrotoxic serum nephritis in the rat.

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