The stimulation of non-specific host resistance to infection by chemically modified endotoxin.
An acetylated derivative prepared from Salmonella typhosa O-901 endotoxin has been found to retain the ability to stimulate non-specific host resistance to a variety of bacterial infections. Relative to the parent endotoxin, the derivative has been reduced in the gross in its pyrogenicity to rabbits and lethality to mice. With the use of this chemically modified preparation under a variety of conditions, the direct dissociation of the toxic properties of endotoxin from its protective capacity appears evident. In young male mice, the endotoxin and its derivative produced a leucocytosis but no leucopenia. However, no direct correlation could be found with the level of the peripheral white blood cells and resistance to infection with Escherichia coli. Furthermore, under the conditions employed, passive transfer of early resistance to infection by serum or plasma was not detectable.
15 references, click to expand
-
Increased resistance to infection and accompanying alteration in properidin levels following administration of bacterial lipopolysaccharides.J Exp Med. 1956 Sep 1;104(3):383-409 PMID: 13357692
-
Reversible changes in the susceptibility of mice to bacterial infections. I. Changes brought about by injection of pertussis vaccine or of bacterial endotoxins.J Exp Med. 1956 Jul 1;104(1):53-65 PMID: 13332180
-
A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system.J Exp Med. 1959 Jul 1;110(1):27-48 PMID: 13664867
-
Stimulation of natural immunity to Escherichia coli infection: observations on mice.Lancet. 1955 Jan 29;268(6857):232-4 PMID: 13234339
-
Further studies on passive transfer of tolerance to pyrogenicity of bacterial endotoxin. The febrile and leucopenic responses.J Exp Med. 1960 Oct 1;112:619-34 PMID: 13701608
-
The resistance-promoting activity of endotoxins and other microbial products. I. Their effect on Salmonella typhosa infections of mice.J Immunol. 1959 Sep;83:302-9 PMID: 14402991
-
Resistance to experimental infection and mobilization of granulocytes in irradiated mice treated with bacterial endotoxin.Am J Physiol. 1958 Feb;192(2):263-7 PMID: 13508866
-
The nature of genetic resistance to infection in mice.Science. 1953 Mar 27;117(3039):328-30 PMID: 13048671
-
The role of opsonins in non-specific immunity.J Exp Med. 1960 Jan 1;111:137-44 PMID: 14439720
-
The virulence of strains of Bacterium coli for mice.Br J Exp Pathol. 1954 Dec;35(6):528-38 PMID: 13230409
-
Changes in the titre of serum opsonins and phagocytic properties of mouse peritoneal macrophages following injection of endotoxin.J Exp Med. 1960 Aug 1;112:419-29 PMID: 13789821
-
Dissociation of the biological properties of bacterial endotoxin by chemical modification of the molecule.J Exp Med. 1962 Dec 1;116:929-42 PMID: 13959422
-
Increase in specific bactericidal antibodies after administration of endotoxin.Nature. 1961 Jul 15;191:296-7 PMID: 13770153
-
Rapidly induced changes in the level of non-specific immunity in laboratory animals.Br J Exp Pathol. 1956 Jun;37(3):223-34 PMID: 13342346
-
Symposium on bacterial endotoxins. II. Possible mechanisms whereby endotoxins evoke increased nonspecific resistance to infection.Bacteriol Rev. 1961 Dec;25:437-46 PMID: 14006483
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