Sequence of the vanY gene required for production of a vancomycin-inducible D,D-carboxypeptidase in Enterococcus faecium BM4147.

Gene ·Vol. 120 ·No. 1 ·1992-10-12 ·Pages 111-4

Arthur M, Molinas C, Courvalin P

Abstract

Cloning and nucleotide sequencing identified the vanY gene as a member of the vancomycin-resistance van gene cluster of enterococcal plasmid, pIP816. The vanY gene was necessary for synthesis of the vancomycin-inducible D,D-carboxypeptidase activity previously proposed to be responsible for glycopeptide resistance. However, this activity was not required for peptidoglycan synthesis in the presence of glycopeptides. The deduced product of vanY did not display significant similarity with other D,D-carboxypeptidases.

Related Genes

vanY

MeSH Terms

Amino Acid Sequence Base Sequence Drug Resistance, Microbial/genetics Enterococcus faecium/enzymology,genetics Enzyme Induction Molecular Sequence Data Muramoylpentapeptide Carboxypeptidase/genetics Vancomycin/pharmacology

Chemicals

Vancomycin Muramoylpentapeptide Carboxypeptidase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Arthur M

Unité des Agents Antibactériens, Institut Pasteur, Paris, France.

Molinas C

Courvalin P

Article Info

Journal

Gene

Abbr.

Gene

ISSN

0378-1119

DOI

10.1016/0378-1119(92)90017-j

Published

1992-10-12

Pages

111-4

Language

English

Region

Netherlands

NLM ID

7706761

Subset

Databases

GENBANK

D10365, D10366, M74891, M74892, M79309, M79310, M90357, M90647, S43297, S45911

External Links

PubMed source DOI: 10.1016/0378-1119(92)90017-j View journal details

Analysis Services

Sequence of the vanY gene required for production of a vancomycin-inducible D,D-carboxypeptidase in Enterococcus faecium BM4147.

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