Molecular conformation of sodium heparan sulphate in the condensed phase.

The Biochemical journal ·Vol. 161 ·No. 3 ·1977-03-01 ·Pages 495-8

Elloway HF, Atkins ED

Abstract

By using the X-ray-diffraction results reported previously for sodium heparan sulphate, a twofold helical conformation with an axially projected disaccharide repeat (h) equal to 0.93 nm has been examined in detail. On the basis of a repeating sequence of 1,4-alpha-D-glucosamine and 1,4-beta-D-glucuronic acid, trial and stereochemically feasible molecular models were computer-generated. An optimum twofold helical conformation is proposed, incorporating stabilizing intra-chain hydrogen bonds across both glycosidic linkages.

MeSH Terms

Glycosaminoglycans Heparitin Sulfate Hydrogen Bonding Models, Molecular Molecular Conformation

Chemicals

Glycosaminoglycans Heparitin Sulfate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Elloway H F

Atkins E D

References (14)

14 references, click to expand

Hyaluronic acid: structure of a fully extended 3-fold helical sodium salt and comparison with the less extended 4-fold helical forms.
J Mol Biol. 1975 Dec 5;99(2):219-35 PMID: 1206703
The effect of calcium on the macromolecular properties of heparan sulfate.
Connect Tissue Res. 1975;3(2):187-93 PMID: 126847
Production of heparin related mucopolysaccharides by mammalian cells in culture.
Proc Soc Exp Biol Med. 1970 Sep;134(4):955-62 PMID: 4195727
Distribution of sulphate and iduronic acid residues in heparin and heparan sulphate.
Biochem J. 1974 Jan;137(1):33-43 PMID: 4206909
Evidence for the existence of a multichain proteoglycan of heparan sulphate.
Biochem J. 1970 May;117(4):699-702 PMID: 4247363
Heparan sulfates of cultured cells. I. Membrane-associated and cell-sap species in Chinese hamster cells.
Biochemistry. 1971 Apr 13;10(8):1437-45 PMID: 4253009
Heparan sulfates of cultured cells. II. Acid-soluble and -precipitable species of different cell lines.
Biochemistry. 1971 Apr 13;10(8):1445-51 PMID: 4253010
X-ray-diffraction patterns from chondroitin 4-sulphate, dermatan sulphate and heparan sulphate.
Biochem J. 1973 Jul;133(3):605-6 PMID: 4270110
High molecular-weight heparan sulfate from the cell surface.
Biochem Biophys Res Commun. 1974 Jan 23;56(2):423-30 PMID: 4274688
The disaccharide repeating-units of heparan sulfate.
Carbohydr Res. 1974 Oct;37(1):181-92 PMID: 4279141
Conformation of polypeptides and proteins.
Adv Protein Chem. 1968;23:283-438 PMID: 4882249
Occurrence and biosynthesis of beta-glucuronidic linkages in heparin.
J Biol Chem. 1971 Sep 10;246(17):5442-7 PMID: 4999355
Rigid-body refinement and conformation of -chitin.
Biochim Biophys Acta. 1972 Jan 28;261(1):123-35 PMID: 5012459
The crystal structure of N-acetyl-alpha-D-glucosamine.
Acta Crystallogr. 1966 Dec 10;21(6):885-91 PMID: 6013453

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1610495

Published

1977-03-01

Pages

495-8

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1164533

Subset

External Links

PubMed source DOI: 10.1042/bj1610495 PMC Full Text View journal details

Analysis Services

Molecular conformation of sodium heparan sulphate in the condensed phase.

Contact

WeChat Official Account