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PMID: 140624 Published · ppublish English Journal Article

Changing patterns of plasmid-mediated drug resistance during tetracycline therapy.

Antimicrobial agents and chemotherapy ·Vol. 11 ·No. 3 ·1977-03-00 ·Pages 388-91

Moller JK, Bak AL, Stenderup A, Zachariae H, Afzelius H

Abstract

The patterns of drug resistance and the frequency of conjugative R plasmids in intestinal Escherichia coli from 88 patients treated for a skin disease (acne vulgaris) with low oral doses of tetracycline are reported. The proportion of patients with resistant bacteria was progressively greater in patients who received tetracycline for 1 week, 4 weeks, or longer (from 50 to 88%). No multiply drug-resistant bacteria were detected before treatment or after 1 week of treatment. After more than 4 weeks of treatment, multiply drug-resistant E. coli were isolated from about 50% of the patients. The origin and selection of R plasmid-determined multiple drug resistance are discussed.

MeSH Terms
Acne Vulgaris/drug therapy Drug Resistance, Microbial Escherichia coli/drug effects,isolation & purification Extrachromosomal Inheritance Feces/microbiology Humans Plasmids R Factors Rosacea/drug therapy Tetracycline/pharmacology,therapeutic use Time Factors
Chemicals
Tetracycline
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Moller J K
Bak A L
Stenderup A
Zachariae H
Afzelius H
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23 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.11.3.388
Published
1977-03-00
Pages
388-91
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC351994
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.11.3.388 PMC Full Text View journal details
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