POLYRIBOSOMES: SIZE IN NORMAL AND POLIO- INFECTED HELA CELLS.

Science (New York, N.Y.) ·Vol. 142 ·No. 3600 ·1963-12-27 ·Pages 1658-63

RICH A, PENMAN S, BECKER Y, DARNELL J, HALL C

Abstract

HeLa cells normally contain a distribution of polysome sizes, and the largest polysomes contain over 40 ribosomes. After infection with polio virus and actinomycin-D treatment, a new class of polio-induced polysomes are found, some of which contain up to 60 ribosomes. Examinaton of these polysomes suggests a mechanism for protein synthesis with this polycistronic RNA.

Keywords

EXPERIMENTAL LAB STUDY NUCLEOPROTEINS POLIOVIRUS PROTEIN METABOLISM RNA RNA VIRAL TISSUE CULTURE

MeSH Terms

HeLa Cells Humans Nucleoproteins Poliomyelitis Poliovirus Polyribosomes Proteins/metabolism RNA RNA, Viral Research Ribosomes Tissue Culture Techniques Virus Cultivation

Chemicals

Nucleoproteins Proteins RNA, Viral RNA

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

RICH A

PENMAN S

BECKER Y

DARNELL J

HALL C

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.142.3600.1658

Published

1963-12-27

Pages

1658-63

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.142.3600.1658 View journal details

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POLYRIBOSOMES: SIZE IN NORMAL AND POLIO- INFECTED HELA CELLS.

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