LOCALIZATION OF ANTIBODIES IN GROUP I AND GROUP II GAMMA-GLOBULINS.

The Journal of experimental medicine ·Vol. 118 ·1963-11-01 ·Pages 817-26

MANNIK M, KUNKEL HG

Abstract

A wide assortment of antibodies has been analysed by qualitative and quantitative techniques for their content of group I- and group II-type gamma-globulin molecules. These included Rh antibodies, isoagglutinins, thyroglobulin antibodies, dextran antibodies, and teichoic acid antibodies. All the antibodies studied showed the presence of both groups. However, the ratio of the two varied widely in different individuals and diverged markedly from the ratio in the total gamma-globulin of the individual. Two antibodies isolated from the serum of the same individual showed different ratios for the two groups.

Keywords

ANTIGEN-ANTIBODY REACTIONS BENCE JONES PROTEIN DEXTRAN ELECTROPHORESIS EXPERIMENTAL LAB STUDY GAMMA GLOBULIN PHOSPHATES RABBITS RH FACTORS THYROGLOBULIN

MeSH Terms

Antibodies Antigen-Antibody Reactions Bence Jones Protein Dextrans Electrophoresis Phosphates Rabbits Research Rh-Hr Blood-Group System Thyroglobulin gamma-Globulins

Chemicals

Antibodies Dextrans Phosphates Rh-Hr Blood-Group System gamma-Globulins Bence Jones Protein Thyroglobulin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

MANNIK M

KUNKEL H G

References (7)

7 references, click to expand

TWO MAJOR TYPES OF NORMAL 7S gamma-GLOBULIN.
J Exp Med. 1963 Jan 31;117(2):213-30 PMID: 19867222
On structural and functional relations between antibodies and proteins of the gamma-system.
Proc Natl Acad Sci U S A. 1962 Jun 15;48:1035-42 PMID: 13889152
CLASSIFICATION OF MYELOMA PROTEINS, BENCE JONES PROTEINS, AND MACROGLOBULINS INTO TWO GROUPS ON THE BASIS OF COMMON ANTIGENIC CHARACTERS.
J Exp Med. 1962 Nov 30;116(6):859-77 PMID: 19867218
Individual Antigenic Specificity of Isolated Antibodies.
Science. 1963 Jun 14;140(3572):1218-9 PMID: 17837506
TWO TYPES OF gamma-MYELOMA PROTEINS, beta(2A)-MYELOMA PROTEINS, gamma(1)-MACROGLOBULINS, AND BENCE JONES PROTEINS IDENTIFIED BY TWO GROUPS OF COMMON ANTIGENIC DETERMINANTS.
J Clin Invest. 1963 Jun;42(6):811-22 PMID: 16695905
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
Antigenic relationships of Bence Jones proteins, myeloma globulins, and normal human gama-globulin.
J Exp Med. 1963 Jan 1;117:81-104 PMID: 13935673

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.118.5.817

Published

1963-11-01

Pages

817-26

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2137674

Subset

External Links

PubMed source DOI: 10.1084/jem.118.5.817 PMC Full Text View journal details

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