Prevention of obesity in Avy/a mice by dehydroepiandrosterone.

Lipids ·Vol. 12 ·No. 5 ·1977-05-00 ·Pages 409-13

Yen TT, Allan JA, Pearson DV, Acton JM, Greenberg MM

Abstract

Dehydroepiandrosterone, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented Avy/a mice from becoming obese. Decreased accumulation of triacylglycerol accounted for a large portion of the weight difference between treated and control Avy/a mice. Hepatic lipogenesis as measured by 3H2O incorporation into total lipid was less in the dehydroepiandrosterone-treated mice. Dehydroepiandrosterone did not suppress appetite and had no apparent toxic effects at the doses used, and its weight controlling effects were reversible upon withdrawal of treatment.

MeSH Terms

Animals Appetite/drug effects Body Weight Dehydroepiandrosterone/pharmacology Dose-Response Relationship, Drug Eating/drug effects Female Liver/metabolism Male Mice Obesity/genetics,metabolism,prevention & control Sex Factors Triglycerides/metabolism

Chemicals

Triglycerides Dehydroepiandrosterone

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Yen T T

Allan J A

Pearson D V

Acton J M

Greenberg M M

References (18)

18 references, click to expand

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Article Info

Journal

Lipids

Abbr.

Lipids

ISSN

0024-4201

DOI

10.1007/BF02533624

Published

1977-05-00

Pages

409-13

Language

English

Region

United States

NLM ID

0060450

Subset

External Links

PubMed source DOI: 10.1007/BF02533624 View journal details

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Prevention of obesity in Avy/a mice by dehydroepiandrosterone.

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