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PMID: 14105220 Published · ppublish English Journal Article

ELECTRON MICROSCOPIC OBSERVATIONS ON THE ACCUMULATION OF DIVALENT CATIONS IN INTRAMITOCHONDRIAL GRANULES.

The Journal of cell biology ·Vol. 20 ·1964-01-00 ·Pages 95-111

PEACHEY LD

Abstract

Electron microscopic evidence is presented, from mitochondria in whole cells of toad urinary bladder and from isolated rat kidney mitochondria, indicating that the divalent cations calcium, strontium, and barium are accumulated in granules localized in the mitochondrial matrix. This accumulation occurs under conditions in which divalent ions are present in the medium bathing either whole cells or isolated mitochondria. The evidence indicates that the divalent ions are deposited on, or in a pre-existing granule, possibly in exchange for other ions. It suggests a possible role of the intramitochondrial granules in the regulation of the internal ionic environment of the mitochondrion. Certain biochemical and physiological implications of this phenomenon are discussed.

Keywords
BARIUM BLADDER CALCIUM EXPERIMENTAL LAB STUDY IONS KIDNEY MAGNESIUM MICROSCOPY ELECTRON MINERAL METABOLISM MITOCHONDRIA RATS STRONTIUM TISSUE CULTURE TOADS
MeSH Terms
Anura Barium Calcium Cations, Divalent Cytoplasmic Granules Electrons Ions Kidney Magnesium Microscopy Microscopy, Electron Minerals/metabolism Mitochondria Rats Research Strontium Tissue Culture Techniques Urinary Bladder
Chemicals
Cations, Divalent Ions Minerals Barium Magnesium Calcium Strontium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
PEACHEY L D
References (20)
20 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.20.1.95
Published
1964-01-00
Pages
95-111
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2106346
Subset
OM
External Links
PubMed source DOI: 10.1083/jcb.20.1.95 PMC Full Text View journal details
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