OBSERVATIONS ON THE RESISTANCE IN HB E THALASSAEMIA DISEASE TO INDUCED INFECTION WITH PLASMODIUM VIVAX.

Bulletin of the World Health Organization ·Vol. 30 ·1964-00-00 ·Pages 51-5

RAY RN, CHATTERJEA JB, CHAUDHURI RN

Abstract

Subjects with sickle cell trait have been known to offer resistance to induced Plasmodium falciparum infection. The resistance to malarial infection in other haemoglobinopathic disorders is not clearly known. Investigations were undertaken to test for resistance to malaria in Hb E thalassaemia disease. Compared to controls, subjects with Hb E thalassaemia disease were found to have significant resistance to induced Plasmodium vivax infection.

Keywords

ANEMIA SICKLE CELL CLINICAL RESEARCH ERYTHROCYTES FETAL HEMOGLOBIN GLUCOSEPHOSPHATE DEHY- DROGENASE DEFICIENCY GLUTATHIONE HEMOGLOBINS ABNORMAL INDIA MALARIA NEGROES PLASMODIUM VIVAX THALASSEMIA UNITED STATES

MeSH Terms

Anemia, Sickle Cell Biomedical Research Blacks Erythrocytes Fetal Hemoglobin Glucosephosphate Dehydrogenase Deficiency Glucosephosphates Glutathione Hemoglobins Hemoglobins, Abnormal Humans India Malaria Plasmodium vivax Sickle Cell Trait Thalassemia United States

Chemicals

Glucosephosphates Hemoglobins Hemoglobins, Abnormal Fetal Hemoglobin Glutathione

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

RAY R N

CHATTERJEA J B

CHAUDHURI R N

References (9)

9 references, click to expand

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Malaria and the sickling trait.
Br Med J. 1955 May 14;1(4923):1186-9 PMID: 14363830
The glutathione instability of drug-sensitive red cells; a new method for the in vitro detection of drug sensitivity.
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Sickle-cell trait and malaria in Africa.
Bull World Health Organ. 1956;15(3-5):837-42 PMID: 13404460
Haemoglobin E and malaria in south-east Thailand.
Ann Trop Med Parasitol. 1961 Dec;55:468-73 PMID: 14459873
Balancing the human hemoglobin polymorphisms.
Hum Biol. 1961 Sep;33:205-19 PMID: 14465994
Erythrocyte glucose-6-phosphate dehydrogenase and malaria in Thailand.
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Br Med J. 1956 Apr 7;1(4970):784-6 PMID: 13304332

Article Info

Journal

Bulletin of the World Health Organization

Abbr.

Bull World Health Organ

ISSN

0042-9686

Published

1964-00-00

Pages

51-5

Language

English

Region

Switzerland

NLM ID

7507052

PMCID

PMC2554904

Subset

External Links

PubMed source PMC Full Text View journal details

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OBSERVATIONS ON THE RESISTANCE IN HB E THALASSAEMIA DISEASE TO INDUCED INFECTION WITH PLASMODIUM VIVAX.

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