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PMID: 14129667 Published · ppublish English Journal Article

RESISTANCE AND CROSS-RESISTANCE OF ESCHERICHIA COLI S MUTANTS TO THE RADIOMIMETIC AGENT PROFLAVINE.

Journal of bacteriology ·Vol. 87 ·1964-03-00 ·Pages 536-42

WOODY-KARRER P, GREENBERG J

Abstract

Woody-Karrer, Pearl (Palo Alto Medical Research Foundation, Palo Alto, Calif.), and Joseph Greenberg. Resistance and cross-resistance of Escherichia coli S mutants to the radiomimetic agent proflavine. J. Bacteriol. 87:536-542. 1964.-All 50 of the first-step mutants of Escherichia coli S selected for resistance to proflavine were resistant to ultraviolet light and each of five different radiomimetic chemicals. The mutants were classified into eight types on the basis of their relative resistance to six different radiomimetic drugs and on the basis of the shape of their ultraviolet survival curves. Three of these types are identical to types previously isolated with other radiomimetic drugs; five of the types are new. A high proportion of the clones surviving proflavine treatment were phenotypically but not genetically resistant, and no strains were isolated which were resistant to proflavine but were not resistant to radiation.

Keywords
ACRIDINES DRUG RESISTANCE MICROBIAL ESCHERICHIA COLI EXPERIMENTAL LAB STUDY MUTATION RADIATION EFFECTS ULTRAVIOLET RAYS
MeSH Terms
Acridines Antimetabolites Drug Resistance, Microbial Escherichia coli Mutation Proflavine Radiation Effects Research Ultraviolet Rays
Chemicals
Acridines Antimetabolites Proflavine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
WOODY-KARRER P
GREENBERG J
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20 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.87.3.536-542.1964
Published
1964-03-00
Pages
536-42
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC277050
Subset
OM
External Links
PubMed source DOI: 10.1128/jb.87.3.536-542.1964 PMC Full Text View journal details
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