PROCAINE ACTION: ANTAGONISM BY ADENOSINE TRIPHOSPHATE AND OTHER NUCLEOTIDES.

Science (New York, N.Y.) ·Vol. 144 ·No. 3623 ·1964-06-05 ·Pages 1222-3

KUPERMAN AS, OKAMOTO M, BEYER AM, VOLPERT WA

Abstract

Appropriate concentrations of adenosine tri-, di-, and monophosphate antagonize the depressant action of procaine on isolated nerve. Some calcium ion is required in the external solution in order for these nucleotides to produce their maximum effects. When applied either to normal or sodium deficient nerves, the nucleotides do not increase action-potential amplitude.

Keywords

ADENINE NUCLEOTIDES ADENOSINE TRIPHOSPHATE CALCIUM EXPERIMENTAL LAB STUDY FROGS NERVE TISSUE PHARMACOLOGY PROCAINE

MeSH Terms

Action Potentials Adenine Nucleotides Adenosine Adenosine Triphosphate Animals Anura Calcium Nerve Tissue Nucleotides Pharmacology Procaine Ranidae Research Sodium

Chemicals

Adenine Nucleotides Nucleotides Procaine Adenosine Triphosphate Sodium Adenosine Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

KUPERMAN A S

OKAMOTO M

BEYER A M

VOLPERT W A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.144.3623.1222

Published

1964-06-05

Pages

1222-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.144.3623.1222 View journal details

Analysis Services

PROCAINE ACTION: ANTAGONISM BY ADENOSINE TRIPHOSPHATE AND OTHER NUCLEOTIDES.

Contact

WeChat Official Account