AGAMMAGLOBULINEMIA: THE FUNDAMENTAL DEFECT.

Science (New York, N.Y.) ·Vol. 145 ·No. 3632 ·1964-08-07 ·Pages 611-2

FUDENBERG HH, HIRSCHHORN K

Abstract

Addition of phytohemagglutinin and of streptolysin S to in vitro cultures of leukocytes of normal and agammaglobulinemic subjects resulted in mitosis of lymphocytes and their differentiation to plasma cells. In contrast, specific antigens induced mitosis and differentiation of lymphocytes of normal but not of agammaglobulinemic donors. The data suggest that the absence of plasma cells in agammaglobulinemia is not in itself responsible for failure of antibody production, but is rather the morphologic concomitant of the primary defect (failure of antibody production on exposure to antigenic stimulus).

Keywords

AGAMMAGLOBULINEMIA ANTIBODY FORMATION ANTIGEN-ANTIBODY REACTIONS CELL DIVISION GAMMA GLOBULIN GENETICS HUMAN LYMPHOCYTES MUTATION PHARMACOLOGY PLANT AGGLUTININS PLASMA CELLS PROTEIN METABOLISM DISORDERS RNA RNA MESSENGER STREPTOLYSIN TISSUE CULTURE

MeSH Terms

Agammaglobulinemia Antibody Formation Antigen-Antibody Reactions Antigens Bacterial Proteins Cell Division Genetics, Medical Humans Immunologic Tests Leukocytes Lymphocytes Mitosis Mutation Pharmacology Plant Lectins Plasma Cells Proteins/metabolism RNA RNA, Messenger Streptolysins Tissue Culture Techniques gamma-Globulins

Chemicals

Antigens Bacterial Proteins Plant Lectins Proteins RNA, Messenger Streptolysins gamma-Globulins streptolysin S RNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

FUDENBERG H H

HIRSCHHORN K

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.145.3632.611

Published

1964-08-07

Pages

611-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.145.3632.611 View journal details

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