PROTEIN SYNTHESIS DURING DEVELOPMENT: CONTROL THROUGH MESSENGER RNA.

Science (New York, N.Y.) ·Vol. 145 ·No. 3633 ·1964-08-14 ·Pages 711-4

SCOTT RB, BELL E

Abstract

Utilization of long-lived messenger RNA appears to be the exception rather than the rule in cells which are differentiating and synthesizing large amounts of specialized product at the same time. The fact that polyribosomes synthesize protein after RNA synthesis is turned off by actinomycin D is used to demonstrate messenger RNA of long half-life. The data suggest that most tissues examined have short-lived messenger RNA's, but the ocular lens can synthesize protein after an incubation of 24 hours in 40 microg of actinomycin D per milliliter. A common basis for the presence of long-lived messenger RNA in the cells of the lens, the feather, and in reticulocytes is discussed.

Keywords

ACTINOMYCIN BRAIN CARBON ISOTOPES CHICK EMBRYO ECHINODERMATA EMBRYO EXPERIMENTAL LAB STUDY FEATHERS LENS CRYSTALLINE LIVER MUSCLE SMOOTH NUCLEOPROTEINS NUCLEOSIDES PHARMACOLOGY PROTEIN METABOLISM RETICULOCYTES RIBOSOMES RNA RNA MESSENGER

MeSH Terms

Animals Brain Carbon Isotopes Chick Embryo Dactinomycin Echinodermata Embryo, Mammalian Embryo, Nonmammalian Feathers Half-Life Lens, Crystalline Liver Muscle, Smooth Muscles Nucleoproteins Nucleosides Pharmacology Protein Biosynthesis Proteins/metabolism RNA RNA, Messenger Research Reticulocytes Ribosomes

Chemicals

Carbon Isotopes Nucleoproteins Nucleosides Proteins RNA, Messenger Dactinomycin RNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

SCOTT R B

BELL E

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.145.3633.711

Published

1964-08-14

Pages

711-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.145.3633.711 View journal details

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