GAMMA GLOBULIN: UNMASKING OF HIDDEN ANTIGENIC SITES ON LIGHT CHAINS.

Science (New York, N.Y.) ·Vol. 145 ·No. 3628 ·1964-07-10 ·Pages 167-70

NACHMAN RL, ENGLE RL

Abstract

Normal light (L) chains cleaved from normal pooled human gamma globulin contain immunologic determinants not overtly present in the native unreduced molecule. These hidden determinants are shared with Bence Jones proteins. Similarly, one of two Bence Jones proteins contained immunologic determinants which were not overtly present on the autologous serum myeloma protein.

Keywords

ANTIGENS BENCE JONES PROTEIN EXPERIMENTAL LAB STUDY GAMMA GLOBULIN GEL DIFFUSION TESTS PRECIPITIN TESTS

MeSH Terms

Antigens Bence Jones Protein Humans Immunodiffusion Multiple Myeloma Peptides Precipitin Tests Research gamma-Globulins

Chemicals

Antigens Peptides gamma-Globulins Bence Jones Protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

NACHMAN R L

ENGLE R L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.145.3628.167

Published

1964-07-10

Pages

167-70

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.145.3628.167 View journal details

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