AMINO ACIDS: INCORPORATION INTO ALPHA- AND BETA-CHAINS OF HEMOGLOBIN BY NORMAL AND THALASSEMIC RETICULOCYTES.

Science (New York, N.Y.) ·Vol. 146 ·No. 3643 ·1964-10-23 ·Pages 530-1

HEYWOOD JD, KARON M, WEISSMAN S

Abstract

After incubation of reticulocytes with radioactive amino acid, the specific activity of the beta-chain of globin from the blood of patients with thalassemia was consistently lower than that of the alpha-chain. In subjects without this disorder, the specific activity of the beta-chain was always equal to or higher than that of the alpha-chain.

Keywords

ANEMIA SICKLE CELL CARBON ISOTOPES EXPERIMENTAL LAB STUDY HEMOGLOBIN LEUCINE LEUKEMIA PROTEIN METABOLISM RETICULOCYTES THALASSEMIA VALINE

MeSH Terms

Amino Acids Anemia, Sickle Cell Carbon Isotopes Globins Hemoglobins Humans Leucine Leukemia Proteins/metabolism Research Reticulocytes Thalassemia Valine

Chemicals

Amino Acids Carbon Isotopes Hemoglobins Proteins Globins Leucine Valine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

HEYWOOD J D

KARON M

WEISSMAN S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.146.3643.530

Published

1964-10-23

Pages

530-1

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.146.3643.530 View journal details

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AMINO ACIDS: INCORPORATION INTO ALPHA- AND BETA-CHAINS OF HEMOGLOBIN BY NORMAL AND THALASSEMIC RETICULOCYTES.

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