HEMOGLOBINS A AND F: FORMATION IN THALASSEMIA AND OTHER HEMOLYTIC ANEMIAS.

Science (New York, N.Y.) ·Vol. 144 ·No. 3618 ·1964-05-01 ·Pages 552-3

MARKS PA, BURKA ER

Abstract

Rates of synthesis of hemoglobin A by erythroid cells from thalassemic subjects are markedly decreased. Formation of hemoglobin F, however, proceeds at similar rates in cells from subjects with thalassemia and other types of hemolytic anemias. A mechanism is suggested regarding the altered patterns of hemoglobin synthesis under conditions of erythropoietic stimulation in subjects with and without thalassemia.

Keywords

CARBON ISOTOPES DNA ERYTHROPOIESIS HEMOGLOBINS ABNORMAL HISTOCYTOCHEMISTRY ISOLEUCINE LEUCINE PROTEIN METABOLISM RIBOSOMES RNA THALASSEMIA

MeSH Terms

Anemia, Hemolytic Carbon Isotopes DNA Erythropoiesis Fetal Hemoglobin Hemoglobin A Hemoglobins Hemoglobins, Abnormal Histocytochemistry Humans Isoleucine Leucine Proteins/metabolism RNA Reticulocytes Ribosomes Thalassemia

Chemicals

Carbon Isotopes Hemoglobins Hemoglobins, Abnormal Proteins Isoleucine RNA DNA Hemoglobin A Fetal Hemoglobin Leucine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

MARKS P A

BURKA E R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.144.3618.552

Published

1964-05-01

Pages

552-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.144.3618.552 View journal details

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