THALIDOMIDE SYNDROME IN MONKEYS.

Science (New York, N.Y.) ·Vol. 146 ·No. 3649 ·1964-12-04 ·Pages 1300-5

DELAHUNT CS, LASSEN LJ

Abstract

Pregnant monkeys were treated with thalidomide after implantation but before formation of the fetal limbs. Two fetuses that were recovered from the treated females had congenital abnormalities. The thalidomide syndrome in the monkeys was manifested by amelia, phocomelia, internal hydrocephaly, facial capillary hemangioma, hypogenesis of the metatarsal bones, and anotia.

Keywords

ABNORMALITIES DRUG-INDUCED EXPERIMENTAL LAB STUDY MONKEYS PREGNANCY PREGNANCY ANIMAL THALIDOMIDE TOXICOLOGIC REPORT

MeSH Terms

Abnormalities, Drug-Induced Animals Embryo Implantation Extremities Female Fetus Haplorhini Humans Metatarsal Bones Pregnancy Pregnancy, Animal Research Syndrome Thalidomide Toxicology

Chemicals

Thalidomide

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

DELAHUNT C S

LASSEN L J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.146.3649.1300

Published

1964-12-04

Pages

1300-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.146.3649.1300 View journal details

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