ACTINOMYCIN D: AN EFFECT ON RAT LIVER HOMOGENATES UNRELATED TO ITS ACTION ON RNA SYNTHESIS.

Science (New York, N.Y.) ·Vol. 146 ·No. 3649 ·1964-12-04 ·Pages 1311-3

REVEL M, HIATT HH, REVEL JP

Abstract

Liver homogenates prepared from rats injected with high doses of actinomycin D show a decrease in polyribosome content and in amino acid incorporation. These effects are not observed in rat liver not subjected to homogenization and are independent of the inhibition of RNA synthesis caused by the antibiotic.

Keywords

ACTINOMYCIN AMINO ACID METABOLISM EXPERIMENTAL LAB STUDY HOMOGENATES LIVER CYTOLOGY METABOLISM MICROSOMES PATHOLOGY PHARMACOLOGY RATS RIBOSOMES RNA

MeSH Terms

Amino Acids/metabolism Dactinomycin Liver/cytology Metabolism Microsomes Pathology Pharmacology RNA Rats Research Ribosomes

Chemicals

Amino Acids Dactinomycin RNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

REVEL M

HIATT H H

REVEL J P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.146.3649.1311

Published

1964-12-04

Pages

1311-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.146.3649.1311 View journal details

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ACTINOMYCIN D: AN EFFECT ON RAT LIVER HOMOGENATES UNRELATED TO ITS ACTION ON RNA SYNTHESIS.

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