STUDIES ON ANTIBODY PRODUCTION. XI. VARIATION IN THE SECONDARY RESPONSE AS A FUNCTION OF THE LENGTH OF THE INTERVAL BETWEEN TWO ANTIGENIC STIMULI.

The Journal of experimental medicine ·Vol. 120 ·1964-12-01 ·Pages 1041-9

FECSIK AI, BUTLER WT, COONS AH

Abstract

As the interval between two antigenic stimuli to mice is lengthened, the magnitude of the response to the second dose increases up to approximately 40 days; thereafter it remains at a fairly constant, high level.

Keywords

ANTIBODY FORMATION DIPHTHERIA TOXOID EXPERIMENTAL LAB STUDY HEMAGGLUTINATION IMMUNIZATION MICE

MeSH Terms

Animals Antibody Formation Diphtheria Toxoid Hemagglutination Immunization Mice Research Vaccination

Chemicals

Diphtheria Toxoid

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

FECSIK A I

BUTLER W T

COONS A H

References (8)

8 references, click to expand

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J Lab Clin Med. 1961 Sep;58:391-404 PMID: 13771680
Differences in primary and secondary immunizability of inbred mice strains.
J Immunol. 1959 Oct;83:448-57 PMID: 13852973
The significance of the inoculation interval in vaccination with polyvalent dysentery and combined typhoid-dysentery-tetanus vaccines.
Acta Microbiol Acad Sci Hung. 1959;6:51-9 PMID: 14436509
Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.
J Immunol. 1954 May;72(5):360-7 PMID: 13163409
Tetanus Prophylaxis and Circulating Antitoxin in Men and Women.
Br Med J. 1940 Dec 28;2(4173):891-5 PMID: 20783462
Participation of the popliteal lymph node and spleen in the production of diphtheria antitoxin in the rabbit.
J Infect Dis. 1954 May-Jun;94(3):306-18 PMID: 13174845
Antibody Response and Systemic Reactions after Inoculation of a New Type of T.A.B.C. Vaccine.
Br Med J. 1941 Mar 22;1(4185):435-40 PMID: 20783580
Poliovirus antibody response after various vaccination schedules and at different ages.
Can Med Assoc J. 1959 Sep 15;81:443-9 PMID: 14419587

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.120.6.1041

Published

1964-12-01

Pages

1041-9

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2137782

Subset

External Links

PubMed source DOI: 10.1084/jem.120.6.1041 PMC Full Text View journal details

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STUDIES ON ANTIBODY PRODUCTION. XI. VARIATION IN THE SECONDARY RESPONSE AS A FUNCTION OF THE LENGTH OF THE INTERVAL BETWEEN TWO ANTIGENIC STIMULI.

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