THE MECHANISM OF THE PRESSOR RESPONSES TO PHYSOSTIGMINE IN THE RAT AND THEIR MODIFICATION BY MEBUTAMATE AND AMYLOBARBITONE.

British journal of pharmacology and chemotherapy ·Vol. 23 ·1964-12-00 ·Pages 540-51

DELLABELLA D, GANDINI A, PRETI M

Abstract

Pressor responses to intravenous injections both of physostigmine and of pilocarpine were smaller in rats anaesthetized with either mebutamate or amylobarbitone than in rats anaesthetized with urethane. The response to electrical stimulation of the hypogastric nerve in the isolated hypogastric nerve-vas deferens preparation was diminished by mebutamate and by amylobarbitone, but not by urethane. Similar results were obtained with the cat isolated splenic nerve-spleen preparation. In the rat anaesthetized with urethane, pressor responses to physostigmine were only partially antagonized by hexamethonium but were completely abolished during "depolarizing" ganglionic block by nicotine or tetramethylammonium. It is suggested that, in addition to the central mechanism, there is a peripheral component in the pressor action of physostigmine and in the antihypertensive actions of mebutamate and amylobarbitone.

Keywords

AMMONIUM COMPOUNDS BARBITURATES BLOOD PRESSURE ELECTRIC STIMULATION EXPERIMENTAL LAB STUDY HEXAMETHONIUM COMPOUNDS HYPOGASTRIC PLEXUS MEBUTAMATE NICOTINE PHARMACOLOGY PHYSOSTIGMINE PILOCARPINE RATS SPLANCHNIC NERVES SPLEEN URETHANE

MeSH Terms

Ammonium Compounds Amobarbital Animals Antihypertensive Agents Barbiturates Blood Pressure Carbamates Cats Electric Stimulation Hexamethonium Compounds Humans Hypogastric Plexus Male Nicotine Pharmacology Physostigmine Pilocarpine Quaternary Ammonium Compounds Rats Research Splanchnic Nerves Spleen Urethane Vas Deferens

Chemicals

Ammonium Compounds Antihypertensive Agents Barbiturates Carbamates Hexamethonium Compounds Quaternary Ammonium Compounds Pilocarpine Urethane Nicotine Physostigmine Amobarbital tetramethylammonium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

DELLABELLA D

GANDINI A

PRETI M

References (23)

23 references, click to expand

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Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1964.tb01609.x

Published

1964-12-00

Pages

540-51

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1704002

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1964.tb01609.x PMC Full Text

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THE MECHANISM OF THE PRESSOR RESPONSES TO PHYSOSTIGMINE IN THE RAT AND THEIR MODIFICATION BY MEBUTAMATE AND AMYLOBARBITONE.

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