ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). 13. IMMUNOLOGICAL STUDIES WITH SYNTHETIC POLYMERS CONTAINING ONLY D- OR D- AND L-ALPHA-AMINO ACIDS.

The Journal of experimental medicine ·Vol. 121 ·1965-03-01 ·Pages 339-49

MAURER PH

Abstract

It has been demonstrated that polymers consisting solely of D-alpha-amino acids are not immunogenic in rabbits, guinea pigs, man, and mouse, whereas the same polymers of L-alpha-amino acids are very effective antigens. This has been attributed to the importance of metabolizability of a polymer in contributing to its immunogenicity. In the glu-lys-ala series of polymers, the immunogenicity of a polymer of 2 L-amino acids and a D-amino acid appears to be governed by the immunogenicity of the 2 L-amino acids. However, some of the specificity may be directed towards configurations containing the D-amino acid. It has been noted that injections of rabbits with polymers of D-amino acids has resulted in a reduced response against the isomeric L polymer.

Keywords

ANTIGEN-ANTIBODY REACTIONS BLOOD EXPERIMENTAL LAB STUDY GUINEA PIGS HEMAGGLUTINATION MICE MICROSCOPY FLUORESCENCE PEPTIDES PRECIPITIN TESTS PROTEIN METABOLISM RABBITS

MeSH Terms

Amino Acids Animals Antibody Formation Antigen-Antibody Reactions Antigens Blood Fluorescence Glutamates Guinea Pigs Hemagglutination Mice Microscopy Microscopy, Fluorescence Organic Chemicals Peptides Polymers Precipitin Tests Proteins/metabolism Rabbits Research

Chemicals

Amino Acids Antigens Glutamates Organic Chemicals Peptides Polymers Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

MAURER P H

References (24)

24 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.121.3.339

Published

1965-03-01

Pages

339-49

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2137961

Subset

External Links

PubMed source DOI: 10.1084/jem.121.3.339 PMC Full Text View journal details

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ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). 13. IMMUNOLOGICAL STUDIES WITH SYNTHETIC POLYMERS CONTAINING ONLY D- OR D- AND L-ALPHA-AMINO ACIDS.

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