THE EFFECT OF SULFINPYRAZONE (ANTURAN) ON PLATELET ECONOMY AND BLOOD COAGULATION IN MAN.

Canadian Medical Association journal ·Vol. 92 ·1965-04-10 ·Pages 818-21

SMYTHE HA, OGRYZLO MA, MURPHY EA, MUSTARD JF

Abstract

Sulfinpyrazone (Anturan) administered in therapeutic doses over a period of several weeks produced prolongation of platelet survival and reduced turnover but with little change in blood coagulation. The changes in platelet survival and turnover were associated with reduced platelet adhesiveness. It is therefore possible to affect platelet economy in man significantly, without producing corresponding effects on blood coagulation.

Keywords

ARTHRITIS RHEUMATOID BLOOD COAGULATION TESTS BLOOD PLATELETS DRUG THERAPY GERIATRICS GOUT MYELOFIBROSIS MYOCARDIAL INFARCT PHLEBITIS PROTHROMBIN TIME SULFINPYRAZONE

MeSH Terms

Arthritis Arthritis, Rheumatoid Blood Coagulation Blood Coagulation Tests Blood Platelets Drug Therapy Geriatrics Gout Humans Male Myocardial Infarction Phlebitis Platelet Adhesiveness Primary Myelofibrosis Prothrombin Time Sulfinpyrazone

Chemicals

Sulfinpyrazone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

SMYTHE H A

OGRYZLO M A

MURPHY E A

MUSTARD J F

References (9)

9 references, click to expand

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Article Info

Journal

Canadian Medical Association journal

Abbr.

Can Med Assoc J

ISSN

0008-4409

Published

1965-04-10

Pages

818-21

Language

English

Region

Canada

NLM ID

0414110

PMCID

PMC1927980

Subset

External Links

PubMed source PMC Full Text

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THE EFFECT OF SULFINPYRAZONE (ANTURAN) ON PLATELET ECONOMY AND BLOOD COAGULATION IN MAN.

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