HEREDITARY ANGIONEUROTIC EDEMA: TWO GENETIC VARIANTS.

Science (New York, N.Y.) ·Vol. 148 ·No. 3672 ·1965-05-14 ·Pages 957-8

ROSEN FS, PENSKY J, DONALDSON V, CHARACHE P

Abstract

Serums of patients with hereditary angioneurotic edema lack inhibitory activity against the esterase derived from the first component of complement. In one group of patients this lack appears to result from failure to synthesize the esterase inhibitor of the first component of complement, whereas in another group of patients an abnormal, nonfunctional protein is synthesized.

Keywords

ALPHA GLOBULIN ANGIONEUROTIC EDEMA BLOOD COMPLEMENT ENZYME INHIBITORS ESTERASES GEL DIFFUSION TESTS GENETICS HUMAN IMMUNOELECTROPHORESIS

MeSH Terms

Alpha-Globulins Angioedema Angioedemas, Hereditary Blood Complement System Proteins Enzyme Inhibitors Esterases Genetic Variation Genetics, Medical Humans Immunodiffusion Immunoelectrophoresis Proteins

Chemicals

Alpha-Globulins Enzyme Inhibitors Proteins Complement System Proteins Esterases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

ROSEN F S

PENSKY J

DONALDSON V

CHARACHE P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.148.3672.957

Published

1965-05-14

Pages

957-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.148.3672.957 View journal details

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