FUNCTIONAL STUDIES OF CULTURED BRAIN TISSUES AS RELATED TO "DEMYELINATIVE DISORDERS".

Science (New York, N.Y.) ·Vol. 148 ·No. 3674 ·1965-05-28 ·Pages 1242-4

BORNSTEIN MB, CRAIN SM

Abstract

The serums from animals with experimental allergic encephalomyelitis and humans with multiple sclerosis produce, in addition to demyelination, rapid, reversible alterations in complex, evoked bioelectric (synaptic) responses of cultured cerebral cortex and spinal cord tissues of the mouse. The active factors are dependent on complement and are not present in serums from normal animals and humans.

Keywords

ANIMALS NEWBORN BLOOD BRAIN ELECTROPHYSIOLOGY CEREBRAL CORTEX COMPLEMENT DEMYELINATION ELECTRIC STIMULATION ENCEPHALOMYELITIS ENCEPHALOMYELITIS ALLERGIC EXPERIMENTAL LAB STUDY HYPERSENSITIVITY MICE MULTIPLE SCLEROSIS PHARMACOLOGY SPINAL CORD TISSUE CULTURE

MeSH Terms

Animals Animals, Newborn Blood Brain/physiology Cerebral Cortex Complement System Proteins Demyelinating Diseases Electric Stimulation Electrophysiology Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental Humans Hypersensitivity Immunologic Tests Mice Multiple Sclerosis Pharmacology Research Spinal Cord Tissue Culture Techniques

Chemicals

Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

BORNSTEIN M B

CRAIN S M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.148.3674.1242

Published

1965-05-28

Pages

1242-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.148.3674.1242 View journal details

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FUNCTIONAL STUDIES OF CULTURED BRAIN TISSUES AS RELATED TO "DEMYELINATIVE DISORDERS".

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