PARTICLES RESEMBLING PAPOVA VIRUSES IN HUMAN CEREBRAL DEMYELINATING DISEASE.

Science (New York, N.Y.) ·Vol. 148 ·No. 3676 ·1965-06-11 ·Pages 1477-9

ZURHEIN G, CHOU SM

Abstract

Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia.

Keywords

DEMYELINATION MICROSCOPY ELECTRON NEUROGLIA PAPOVAVIRUS PATHOLOGY VIRUS DISEASES

MeSH Terms

Brain Diseases Cell Nucleus DNA Viruses Demyelinating Diseases Electrons Humans Leukoencephalopathy, Progressive Multifocal Microscopy Microscopy, Electron Neuroglia Oligodendroglia Oncogenic Viruses Pathology Virus Diseases Viruses

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

ZURHEIN G

CHOU S M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.148.3676.1477

Published

1965-06-11

Pages

1477-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.148.3676.1477 View journal details

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