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PMID: 1430231 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immune complex processing in patients with systemic lupus erythematosus. In vivo imaging and clearance studies.

The Journal of clinical investigation ·Vol. 90 ·No. 5 ·1992-11-00 ·Pages 2075-83

Davies KA, Peters AM, Beynon HL, Walport MJ

Abstract

Abnormal processing of immune complexes (IC) may be important in the pathogenesis of systemic lupus erythematosus (SLE). The clearance of large soluble IC (comprising hepatitis B surface antigen (HBsAg)/anti-HBsAg) radiolabeled with 123I was examined in 12 normal subjects and 10 patients with SLE. IC localization was analyzed by static and dynamic gamma-scintigraphy. Initial IC clearance from blood was more rapid in patients (median t1/2 = 2.15 min) than normals (median t1/2 = 5.15 min) due to more rapid uptake in the liver. However, in the SLE group, up to 12% of complexes were released from the liver after 30-50 min. Splenic uptake of immune complexes was reduced in the patients and there was reduced ability to retain IC in this organ. Plasma complement levels and erythrocyte complement receptor type 1 numbers were reduced in the patients, resulting in defective opsonization of IC and reduced red cell binding in vivo. These observations support the hypothesis that IC handling is abnormal in SLE.

MeSH Terms
Adult Antigen-Antibody Complex/metabolism Female Hepatitis B Surface Antigens/metabolism Humans Lupus Erythematosus, Systemic/immunology Male Metabolic Clearance Rate Middle Aged Receptors, Complement 3b/analysis Spleen/metabolism
Chemicals
Antigen-Antibody Complex Hepatitis B Surface Antigens Receptors, Complement 3b
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Davies K A
Rheumatology Unit, Hammersmith Hospital, London, United Kingdom.
Peters A M
Beynon H L
Walport M J
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI116090
Published
1992-11-00
Pages
2075-83
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC443274
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI116090 PMC Full Text View journal details
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