EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY.

The Journal of experimental medicine ·Vol. 122 ·1965-08-01 ·Pages 263-75

BOREL Y, FAUCONNET M, MIESCHER PA

Abstract

In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals. Animals treated with 6-MP during primary response exhibited a preferential 19S response when challenged in the anamnestic response. Animals immunized with small doses of antigen and treated with 6-MP only during the secondary response, reversed the usual antibody pattern and responded with preferential 19S antibody formation.

Keywords

ANTIBODIES ANTIBODY FORMATION ANTIGENS CHROMATOGRAPHY EXPERIMENTAL LAB STUDY GAMMA GLOBULIN 19S GAMMA GLOBULIN 7S MERCAPTOPURINE MICE PHARMACOLOGY RABBITS ULTRACENTRIFUGATION

MeSH Terms

Animals Antibodies Antibody Formation Antigens Chromatography Erythrocytes Immunization Immunoglobulin G Immunoglobulin M Mercaptopurine Mice Pharmacology Rabbits Research Ultracentrifugation gamma-Globulins

Chemicals

Antibodies Antigens Immunoglobulin G Immunoglobulin M gamma-Globulins Mercaptopurine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

BOREL Y

FAUCONNET M

MIESCHER P A

References (8)

8 references, click to expand

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Interaction of the rheumatoid factor with antigen-antibody complexes and aggregated gamma globulin.
J Exp Med. 1958 Jul 1;108(1):105-20 PMID: 13549644
The treatment of autoimmune hemolytic anemia with 6-mercaptopurine and thioguanine.
Blood. 1962 Apr;19:483-500 PMID: 13909724
THE EFFECT OF 6-MERCAPTOPURINE ON IMMUNE RESPONSE IN MAN.
N Engl J Med. 1964 Jul 2;271:16-22 PMID: 14148223
THE HETEROGENEITY OF THE IMMUNE RESPONSE.
Science. 1964 Jul 31;145(3631):457-64 PMID: 14163764
INHIBITION OF 19S ANTIBODY SYNTHESIS BY 7S ANTIBODY.
Science. 1964 Jul 24;145(3630):395-7 PMID: 14172600
THE IMMUNOGLOBULINS OF MICE. I. FOUR MAJOR CLASSES OF IMMUNOGLOBULINS: 7S GAMMA-2-, 7S GAMMA-1-, GAMMA-1A (BETA-2A)-, AND 18S GAMMA-1M-GLOBULINS.
J Exp Med. 1964 Aug 1;120:223-42 PMID: 14208249
7S VERSUS 19S ANAMNESTIC RESPONSE IN RABBITS.
Proc Soc Exp Biol Med. 1964 Nov;117:603-7 PMID: 14233507

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.122.2.263

Published

1965-08-01

Pages

263-75

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2138064

Subset

External Links

PubMed source DOI: 10.1084/jem.122.2.263 PMC Full Text View journal details

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EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY.

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