THE DYNAMICS OF RETICULOENDOTHELIAL BLOCKADE.

The Journal of experimental medicine ·Vol. 122 ·1965-07-01 ·Pages 117-42

KOENIG MG, HEYSSEL RM, MELLY MA, ROGERS DE

Abstract

The dynamics of "reticuloendothelial blockade" were studied in living rabbits and isolated, perfused rabbit livers utilizing gelatin as a blockading agent and Au(198) stabilized in gelatin as a tracer. Employing the above experimental model, the following observations were made. (a) RES blockade was specific and dependent on the surface properties of the particle under study. (b) RES blockade was not caused by saturation of hepatic removal mechanisms. (c) RES blockade was not caused by depletion of demonstrable serum opsonins. (d) RES blockade appeared to correlate with high circulating levels of the blockading agent, per se. Thus, under the conditions employed, the term "reticuloendothelial blockade" was a misnomer. Although specificity of liver macrophage-particle interaction was evident and deserves further study, the data suggest that blockade as usually studied is a laboratory phenomenon induced by the continuing circulation of the blockading agent.

Keywords

BLOOD EXPERIMENTAL LAB STUDY GELATIN GOLD ISOTOPES LIVER FUNCTION OPSONINS PERFUSION RABBITS RETICULOENDOTHELIAL SYSTEM

MeSH Terms

Animals Blood Gelatin Gold Isotopes Kupffer Cells Liver/physiology Mononuclear Phagocyte System Opsonin Proteins Perfusion Phagocytosis Rabbits Research

Chemicals

Gold Isotopes Opsonin Proteins Gelatin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

KOENIG M G

HEYSSEL R M

MELLY M A

ROGERS D E

References (23)

23 references, click to expand

STUDIES OF THE RETICULOENDOTHELIAL SYSTEM (RES). 3. BLOCKADE OF THE RES IN MAN.
J Clin Invest. 1964 Aug;43:1525-32 PMID: 14201537
Clearance rate in relation to agglutinins for gelatin-stabilized colloid in the rat.
Am J Physiol. 1963 Apr;204:655-9 PMID: 13936765
The effect of thorotrast on the removal of bacteria in the splanchnic area of the intact animal.
J Immunol. 1952 Mar;68(3):293-6 PMID: 14938545
STREPTOCOCCAL M PROTEIN ANTIBODIES.
J Infect Dis. 1963 Jul-Aug;113:33-8 PMID: 14044090
A comparison of the removal of mucoid and non-mucoid variants of Klebsiella pneumoniae type B from the splanchnic circulating blood of the intact animal.
J Immunol. 1950 Mar;64(3):131-7 PMID: 15412244
THE EVOLUTION OF THE IMMUNE RESPONSE. 3. IMMUNOLOGIC RESPONSES IN THE LAMPREY.
J Exp Med. 1964 Dec 1;120:1151-68 PMID: 14238932
A COMPARISON OF THE EFFECTS OF HIGH AND LOW VISCOSITY GELATINS AFTER THEIR INTRAVENOUS INJECTION IN MAN.
J Clin Invest. 1946 Mar;25(2):226-36 PMID: 16695311
Studies on bacteriemia. I. Mechanisms relating to the persistence of bacteriemia in rabbits following the intravenous injection of staphylococci.
J Exp Med. 1956 Jun 1;103(6):713-42 PMID: 13319588
Fate of staphylococci within human leukocytes.
J Exp Med. 1960 Dec 1;112:1121-30 PMID: 13769271
The mechanism of blockade of the reticuloendothelial system.
J Exp Med. 1963 Jan 1;117:139-47 PMID: 13936766
Some histological and functional aspects of lymphoid tissue in germfree animals. II. Studies on phagocytosis in vivo.
Ann N Y Acad Sci. 1959 May 8;78:247-53 PMID: 13838173
The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice.
Br J Exp Pathol. 1955 Jun;36(3):226-35 PMID: 13239977
Studies on bacteriemia. III. The blood stream clearance of Escherichia coli in rabbits.
J Exp Med. 1957 Feb 1;105(2):113-24 PMID: 13406172
The role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system.
J Exp Med. 1961 Sep 1;114:363-74 PMID: 13789822
A comparative survey of the phagocytosis of different species of bacteria by Kupffer cells; perfusion studies with the isolated rat liver.
Br J Exp Pathol. 1959 Apr;40(2):113-7 PMID: 13638492
Effect of x-radiation and antihistamine drugs on the reticuloendothelial system measured with colloidal radiogold.
Am J Physiol. 1951 Mar;164(3):822-31 PMID: 14819308
The splanchnic removal in rabbits during fatal bacteremias of the circulating organisms and of superimposed non-pathogenic bacteria.
J Exp Med. 1950 Jul 1;92(1):45-9 PMID: 15422096
Studies on bacteriemia. V. The effect of simultaneous leukopenia and reticuloendothelial blockade on the early blood stream clearance of staphylococci and Escherichia coli.
J Exp Med. 1961 Jun 1;113:1053-66 PMID: 13722011
Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity.
Br J Exp Pathol. 1953 Aug;34(4):441-57 PMID: 13093915
Quantitative study of the granulopectic activity of the reticulo-endothelial system. III. The effect of cortisone and nitrogen mustard on the regenerative capacity of the R.E.S. after saturation with carbon.
Br J Exp Pathol. 1954 Apr;35(2):97-106 PMID: 13149728
Host mechanisms which act to remove bacteria from the blood stream.
Bacteriol Rev. 1960 Mar;24(1):50-66 PMID: 14438353
Studies of the reticuloendothelial system (RES). I. Measurement of the phagocytic capacity of the RES in man and dog.
J Clin Invest. 1963 Mar;42:417-26 PMID: 13956267
Glomerular lesions and the nephrotic syndrome in rabbits given saccharated iron oxide intravenously; with special reference to the part played by intracapillary precipitates in the pathogenesis of the lesions.
J Exp Med. 1956 Jan 1;103(1):127-44 PMID: 13278460

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.122.1.117

Published

1965-07-01

Pages

117-42

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2138031

Subset

External Links

PubMed source DOI: 10.1084/jem.122.1.117 PMC Full Text View journal details

Analysis Services

THE DYNAMICS OF RETICULOENDOTHELIAL BLOCKADE.

Contact

WeChat Official Account