THE ENHANCEMENT OF 19S ANTIBODY PRODUCTION BY PARTICULATE ANTIGEN.
Injection of human thyroglobulin solution into rabbits gave rise to a transient 19S antibody response which could however be maintained by repeated administration of antigen. When the antigen was coated onto acrylic resin particles, the titre of 19S antibodies was increased nearly 20-fold whereas 7S antibody levels were unchanged. This selective enhancement of 19S antibody synthesis by particulate antigen was also seen using human gamma-globulin. "Intermediate" sedimenting and 7S gamma(1)-antibodies were also increased in animals given particulate antigen. These phenomena may be due to prolonged persistence of the antigen in appropriate macrophages or perhaps to an increased uptake into these cells. The results are discussed in terms of the relationship between 19S and 7S globulin-producing cells.
13 references, click to expand
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A stable sheep cell preparation for detecing thyroglobulin auto-antibodies and its clinical applications.J Clin Pathol. 1961 Nov;14:654-60 PMID: 13895879
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THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.J Exp Med. 1964 Jan 1;119:21-39 PMID: 14113114
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Application of a microtechnique to viral serological investigations.J Immunol. 1962 Mar;88:320-9 PMID: 13910995
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ON THE DIFFERENT MOLECULAR FORMS OF ANTIBODY SYNTHESIZED BY RABBITS DURING THE EARLY RESPONSE TO A SINGLE INJECTION OF PROTEIN AND CELLULAR ANTIGENS.Proc Natl Acad Sci U S A. 1961 Oct;47(10):1667-80 PMID: 16590890
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