IMMUNITY IN EXPERIMENTAL SYPHILIS. 3. ATTENUATION OF VIRULENT TREPONEMA PALLIDIUM BY GAMMA-IRRADIATION.

Journal of bacteriology ·Vol. 90 ·1965-08-00 ·Pages 297-301

MILLER JN

Abstract

Miller, James N. (University of California School of Medicine, Los Angeles). Immunity in experimental syphilis. III. Attenuation of virulent Treponema pallidum by gamma-irradiation. J. Bacteriol. 90:297-301. 1965.-Virulent, freshly isolated cells of Treponema pallidum strain Nichols suspended in a 50% rabbit serum-saline solution and exposed to a gamma-irradiation dosage of 652,800 r were rendered noninfectious without apparent loss of motility or change in observable morphological and staining characteristics. Although 5 x 10(7) gamma-irradiated organisms failed to elicit an immobilizing antibody response in rabbits, the same organisms retained their capacity to react with classical T. pallidum-immobilizing antibody.

Keywords

ANTIGEN-ANTIBODY REACTIONS EXPERIMENTAL LAB STUDY IMMUNITY RABBITS RADIATION EFFECTS STAINS AND STAINING SYPHILIS TREPONEMA IMMOBILIZATION TEST TREPONEMA PALLIDUM VIRULENCE

MeSH Terms

Animals Antigen-Antibody Reactions Coloring Agents Immunity Rabbits Radiation Effects Research Staining and Labeling Syphilis Treponema Treponema Immobilization Test Treponema pallidum Virulence

Chemicals

Coloring Agents

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

MILLER J N

References (8)

8 references, click to expand

STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. I. IMMUNOLOGIC RESPONSE OF RABBITS IMMUNIZED WITH REITER PROTEIN ANTIGEN AND CHALLENGED WITH VIRULENT TREPONEMA PALLIDUM.
Br J Vener Dis. 1963 Sep;39:195-8 PMID: 14066175
The relationship of treponemal immobilizing antibody to immunity in syphilis.
Trans Assoc Am Physicians. 1950;63:112-7 PMID: 14855563
IMMUNOGENICITY OF GAMMA-IRRADIATED MYCOBACTERIUM TUBERCULOSIS H37RV (GIV) IN MICE.
Am Rev Respir Dis. 1963 Dec;88:827-32 PMID: 14087235
Further attempts to immunize rabbits with killed Treponema pallidum.
Am J Syph Gonorrhea Vener Dis. 1951 Nov;35(6):568-72 PMID: 14885626
Antigenicity in rabbits and relation to immunity.
Public Health Rep. 1962 May;77(5):431-436 PMID: 19316412
A simple medium for maintaining the viability of Treponema pallidum in the Treponema pallidum immobilization test.
Am J Syph Gonorrhea Vener Dis. 1954 Sep;38(5):429-33 PMID: 13189037
STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. II. TREPONEMA PALLIDUM IMMOBILIZATION (TPI) ANTIBODY AND THE IMMUNE RESPONSE.
Br J Vener Dis. 1963 Sep;39:199-203 PMID: 14066176
Sensitivity of the Treponema pallidum immobilization (TPI) test; a function of the number of spirochaetes in the antigen.
Br J Vener Dis. 1958 Dec;34(4):246-9 PMID: 13618569

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.90.2.297-301.1965

Published

1965-08-00

Pages

297-301

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC315641

Subset

External Links

PubMed source DOI: 10.1128/jb.90.2.297-301.1965 PMC Full Text View journal details

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IMMUNITY IN EXPERIMENTAL SYPHILIS. 3. ATTENUATION OF VIRULENT TREPONEMA PALLIDIUM BY GAMMA-IRRADIATION.

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