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PMID: 14348191 Published · ppublish English Journal Article

REGULATION OF XANTHINE DEHYDROGENASE IN CHICK LIVER. EFFECT OF STARVATION AND OF ADMINISTRATION OF PURINES AND PURINE NUCLEOSIDES.

The Biochemical journal ·Vol. 94 ·1965-02-00 ·Pages 309-13

STIRPE F, DELLACORTE E

Abstract

1. The xanthine-dehydrogenase activity of chick liver, expressed per mg. of nitrogen, is increased during starvation. 2. Administration of inosine and possibly of adenine has a comparable effect on the xanthine dehydrogenase, and also induces an elevation of the total quantity of enzyme. Hypoxanthine, xanthine, guanine, xanthosine, guanosine and adenosine are ineffective. Cortisone is equally ineffective. 3. The administration of puromycin abolishes the effect of inosine and reduces that of starvation. It is concluded that inosine induces an increased synthesis of xanthine dehydrogenase, whereas during starvation the enzyme is spared with respect to other liver proteins. 4. The hypothesis is formulated that chick-liver xanthine dehydrogenase is an adaptive enzyme, its activity being regulated by inosine or by one of its metabolites.

Keywords
CORTISONE EXPERIMENTAL LAB STUDY GUANINE HYPOXANTHINES LIVER ENZYMOLOGY NUCLEOSIDES PHARMACOLOGY POULTRY PUROMYCIN SPECTROPHOTOMETRY STARVATION XANTHINE OXIDASE XANTHINES
MeSH Terms
Adenine Adenosine Animals Chickens Cortisone Guanine Guanosine Hypoxanthines Inosine Liver/enzymology Nucleosides Pharmacology Poultry Purine Nucleosides Purines Puromycin Research Ribonucleosides Spectrophotometry Starvation Xanthine Dehydrogenase Xanthine Oxidase Xanthines
Chemicals
Hypoxanthines Nucleosides Purine Nucleosides Purines Ribonucleosides Xanthines Guanosine Puromycin Inosine Guanine xanthosine Xanthine Dehydrogenase Xanthine Oxidase Adenine Adenosine Cortisone purine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
STIRPE F
DELLACORTE E
References (30)
30 references, click to expand
  1. An elevated xanthine oxidase in livers of vitamin E-deficient rabbits.
    J Biol Chem. 1953 May;202(1):213-5 PMID: 13061447
  2. Biosynthesis of the purines. II. Metabolism of 4-amino-5-imidazolecarboxamide in pigeon liver.
    J Biol Chem. 1952 May;196(2):513-26 PMID: 12980994
  3. A relationship of vitamin E to nucleic acid metabolism.
    J Biol Chem. 1951 Dec;193(2):743-7 PMID: 14907763
  4. A photometric method for avian liver xanthine dehydrogenase.
    Nature. 1957 Oct 12;180(4589):761-3 PMID: 13477275
  5. Xanthine oxidase and liver nitrogen variation with dietary protein.
    J Biol Chem. 1950 Dec;187(2):605-11 PMID: 14803442
  6. Studies on factors affecting the levels of urea cycle enzymes in rat liver.
    J Biol Chem. 1963 Mar;238:1012-8 PMID: 13991730
  7. Relation of cortisone and synthesis of ribonucleic acid to induced and developmental enzyme formation.
    J Biol Chem. 1963 Apr;238:1548-51 PMID: 13950184
  8. The enzymic oxidation and assay of adenine.
    Biochem J. 1952 Jan;50(3):404-7 PMID: 14915965
  9. Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver.
    J Biol Chem. 1962 Jun;237:1921-4 PMID: 14498420
  10. The specificity of xanthine oxidase.
    Biochem J. 1938 Mar;32(3):494-502 PMID: 16746646
  11. Some factors affecting kidney transamidinase activity in rats.
    J Biol Chem. 1960 Aug;235:2362-4 PMID: 13823290
  12. Apparent simultaneous adaptive enzyme formation in C57 mice.
    Science. 1954 Sep 24;120(3117):502-3 PMID: 13195687
  13. De novo synthesis of hypoxanthine via inosine-5-phosphate and inosine.
    J Biol Chem. 1951 Jun;190(2):611-31 PMID: 14841212
  14. A new cyclic dipeptide from peptone.
    Nature. 1960 Dec 24;188:1112 PMID: 13753453
  15. Hormones and liver cytoplasm. 2. Adenosine triphosphatase, glucose 6-phosphatase and xanthine oxidase as affected by hypophysectomy, growth-hormone treatment and adrenalectomy.
    Biochem J. 1956 Dec;64(4):730-4 PMID: 13382826
  16. A colorimetric assay for xanthine oxidase in rat liver homogenates.
    J Biol Chem. 1953 Jan;200(1):303-10 PMID: 13034787
  17. Xanthine oxidase activity in regenerating liver.
    J Gen Physiol. 1957 Nov 20;41(2):233-42 PMID: 13475688
  18. [Distribution of xanthine oxidase in various species of birds; presence of xanthine oxidase in the liver in various species and problem of urico-synthesis in birds].
    Arch Sci Biol (Bologna). 1953 Nov-Dec;37(6):605-10 PMID: 13139937
  19. An analysis of the kinetics of rat liver tryptophan pyrrolase induction: the significance of both enzyme synthesis and degradation.
    Biochem Biophys Res Commun. 1964 Mar 26;15(3):214-9 PMID: 5835384
  20. Metabolic control of creatine biosynthesis. I. Effect of dietary creatine.
    J Biol Chem. 1960 Aug;235:2357-61 PMID: 13842518
  21. Studies on Xanthine Oxidase: The Specificity of the System.
    Biochem J. 1926;20(4):703-18 PMID: 16743712
  22. Factors affecting the induction of xanthine oxidase of mouse liver.
    J Biol Chem. 1954 Nov;211(1):79-85 PMID: 13211644
  23. Turnover of rat liver arginase.
    Ann N Y Acad Sci. 1963 Jan 21;102:587-601 PMID: 13991729
  24. Adaptive characteristics of urea cycle enzymes in the rat.
    J Biol Chem. 1962 Feb;237:459-68 PMID: 14498419
  25. [Urinary allantoin in deficiency of animal protein factors (FPA) of casein].
    Boll Soc Ital Biol Sper. 1956 Mar-May;32(3-5):211-2 PMID: 13342228
  26. [Behavior of xanthinoxidase in rat liver during deficiency of animal protein factors].
    Boll Soc Ital Biol Sper. 1956 Sep;32(9):1149-51 PMID: 13412946
  27. Vitamin E deficiency and xanthine oxidase in rabbits.
    Proc Soc Exp Biol Med. 1953 Nov;84(2):468-70 PMID: 13121075
  28. Xanthine oxidase in different species.
    Proc Soc Exp Biol Med. 1951 Feb;76(2):252-4 PMID: 14827888
  29. The oxidation of reduced xanthine dehydrogenase in chicken liver.
    Biochim Biophys Acta. 1955 Feb;16(2):258-63 PMID: 14363260
  30. [Behavior of xanthine oxidase in inanition and in caloric and rice-diet malnutrition].
    Sperimentale. 1957 Nov-Dec;107(6):471-80 PMID: 13543527
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj0940309
Published
1965-02-00
Pages
309-13
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1206511
Subset
OM
External Links
PubMed source DOI: 10.1042/bj0940309 PMC Full Text View journal details
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