Studies on the mechanism of the Shwartzman phenomenon; similarities between reactions to endotoxins and certain reactions of bacterial allergy.
The cutaneous, ophthalmic, and systemic reactions of normal rabbits to Gram-negative bacterial endotoxins have been compared with the classical reactions of bacterial hypersensitivity, and in each case certain similarities have been found. It has also been shown that the Shwartzman phenomenon can be reproduced with tuberculin, in BCG-vaccinated rabbits, and with suspensions or extracts of heat-killed Group A streptococci in rabbits previously sensitized to these bacteria. These considerations suggest the hypothesis that the biologic activity of endotoxins may be based on the existence in "normal" animals of delayed or tuberculin-type hypersensitivity to these materials.
11 references, click to expand
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Studies on the generalized Shwartzman reaction: I. General observations concerning the phenomenon.J Exp Med. 1952 Dec;96(6):605-24 PMID: 13022854
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Studies on the generalized Shwartzman reaction. III. Lesions of the myocardium and coronary arteries accompanying the reaction in rabbits prepared by infection with group A streptococci.J Exp Med. 1953 May;97(5):751-66 PMID: 13052831
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Tuberculin type sensitivity to spinal cord antigen in rabbits with isoallergic encephalomyelitis.J Immunol. 1951 Apr;66(4):421-44 PMID: 14824544
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Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis.J Exp Med. 1951 May;93(5):489-504 PMID: 14832396
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The persistence in mice of certain foreign proteins and azoprotein tracer-antigens derived from them.J Exp Med. 1951 Oct;94(4):323-46 PMID: 14888815
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Similarities in the mechanisms determining the Arthus and Shwartzman phenomena.J Exp Med. 1951 Oct;94(4):347-58 PMID: 14888816
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Induction of cardiac lesions, closely resembling those of rheumatic fever, in rabbits following repeated skin infections with group A streptococci.J Exp Med. 1949 Jun 1;89(6):687-98 PMID: 18129867
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REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : I. GENERAL TUBERCULIN-LIKE HYPERSENSITIVENESS, ALLERGY, OR HYPERERGY FOLLOWING THE SECONDARY REACTION.J Exp Med. 1929 Mar 31;49(4):615-36 PMID: 19869568
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REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : II. SKIN REACTIONS IN INTRAVENOUSLY IMMUNIZED ANIMALS.J Exp Med. 1929 Apr 30;49(5):883-97 PMID: 19869588
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HEMORRHAGES IN TUBERCULOUS GUINEA PIGS AT THE SITE OF INJECTION OF IRRITANTS FOLLOWING INTRAVASCULAR INJECTIONS OF INJURIOUS SUBSTANCES (SHWARTZMAN PHENOMENON).J Exp Med. 1934 Nov 30;60(6):669-85 PMID: 19870331
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TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI.J Exp Med. 1936 Aug 31;64(3):355-68 PMID: 19870540
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