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PMID: 1439783 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

What if Minkowski had been ageusic? An alternative angle on diabetes.

Science (New York, N.Y.) ·Vol. 258 ·No. 5083 ·1992-10-30 ·Pages 766-70

McGarry JD

Abstract

Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.

MeSH Terms
3-Hydroxybutyric Acid Acetoacetates/blood Adipose Tissue/metabolism Blood Glucose/metabolism Diabetes Mellitus, Type 1/metabolism Diabetes Mellitus, Type 2/genetics,metabolism Fatty Acids, Nonesterified/blood,metabolism Glucose Tolerance Test Humans Hydroxybutyrates/blood Insulin/blood Insulin Resistance Islets of Langerhans/physiopathology Ketone Bodies/blood,metabolism Lipid Metabolism Lipoproteins, VLDL/biosynthesis Liver/metabolism Triglycerides/metabolism
Chemicals
Acetoacetates Blood Glucose Fatty Acids, Nonesterified Hydroxybutyrates Insulin Ketone Bodies Lipoproteins, VLDL Triglycerides acetoacetic acid 3-Hydroxybutyric Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
McGarry J D
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.1439783
Published
1992-10-30
Pages
766-70
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIDDK NIH HHS · DK11313 · United States
NIDDK NIH HHS · DK18573 · United States
External Links
PubMed source DOI: 10.1126/science.1439783 View journal details
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