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PMID: 14409703 Published · ppublish English Journal Article

Studies on the antigenic properties of complement. II. Analysis of specific agglutinins against certain components of guinea pig complement fixed on sensitized sheep erythrocytes.

The Journal of experimental medicine ·Vol. 111 ·1960-01-01 ·Pages 107-17

KLEIN PG, BURKHOLDER PM

Abstract

Sheep erythrocytes sensitized with amboceptor and persensitized thereafter with guinea pig complement are agglutinated by rabbit anti-guinea pig globulin and by immune sera obtained by injection of rabbits with fixed complement. In this agglutination neither C'1 nor C'2 takes part. Fixed C'4 acts as an agglutinogen. An additional agglutinogen, distinct from C'4, was found on persensitized cells. This additional agglutinogen appears to be distinct from hemolytically active C'3.

Keywords
COMPLEMENT
MeSH Terms
Agglutinins Animals Complement System Proteins Erythrocytes Guinea Pigs Hemolysis Immune Sera Rabbits Sheep
Chemicals
Agglutinins Immune Sera Complement System Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
KLEIN P G
BURKHOLDER P M
References (4)
4 references, click to expand
  1. Immunological estimation of a component of complement.
    Nature. 1958 Jun 14;181(4624):1667-8 PMID: 13566107
  2. Studies on the antigenic properties of complement. I. Demonstration of agglutinating antibodies against guinea pig complement fixed on sensitized sheep erythrocytes.
    J Exp Med. 1960 Jan 1;111:93-106 PMID: 14409702
  3. Studies on immune hemolysis: preparation of a stable and highly reactive complex of sensitized erythrocytes and the first component of complement (EAC'1): inactivation of cell-fixed C'1 by some complement reagents.
    J Exp Med. 1960 Jan 1;111:77-91 PMID: 13848490
  4. Studies on the mechanism of inactivation of human complement by plasmin and by antigen-antibody aggregates. I. The requirement for a factor resembling C'1 and the role of Ca++.
    J Immunol. 1954 Sep;73(3):146-58 PMID: 13201755
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1960-01-01
Pages
107-17
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2137193
Subset
OM
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