The effect of enzyme inhibitors on histamine catabolism in man.

British journal of pharmacology and chemotherapy ·Vol. 15 ·1960-06-00 ·Pages 351-5

LINDELL SE, NILSSON K, ROOS BE, WESTLING H

Abstract

The catabolism of histamine was studied in three female psychiatric patients by analysis of the [(14)C]-labelled metabolic products occurring in the urine after a subcutaneous injection of [(14)C]histamine. Each patient was studied before and during treatment with aminoguanidine or iproniazid.Without treatment the patients had a normal histamine catabolism. Aminoguanidine and iproniazid inhibited the oxidation of histamine to imidazoleacetic acid; iproniazid produed a 50% inhibition of the oxidation of methylhistamine to methylimidazoleacetic acid. After iproniazid a large proportion of the injected [C(14)]histamine was excreted as methyl [(14)C]histamine.

Keywords

HISTAMINASE/antagonists HISTAMINE/metabolism

MeSH Terms

Amine Oxidase (Copper-Containing)/antagonists & inhibitors Enzyme Inhibitors Female Guanidines Histamine/metabolism Imidazoles Iproniazid Methylhistamines

Chemicals

Enzyme Inhibitors Guanidines Imidazoles Methylhistamines methylimidazoleacetic acid Histamine Iproniazid Amine Oxidase (Copper-Containing) imidazoleacetic acid pimagedine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

LINDELL S E

NILSSON K

ROOS B E

WESTLING H

References (11)

11 references, click to expand

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The influence of amine oxidase inhibitors on epinephrine metabolism in man.
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Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1960.tb01255.x

Published

1960-06-00

Pages

351-5

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1481924

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1960.tb01255.x PMC Full Text

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