Illuminating adhesion complexes in migrating cells: moving toward a bright future.

Current opinion in cell biology ·Vol. 15 ·No. 5 ·2003-10-00 ·Pages 614-20

Webb DJ, Brown CM, Horwitz AF

Abstract

Cell migration is a complex, tightly regulated process that involves the continuous formation and disassembly of adhesions. Despite the importance of these processes, very little is known about the factors that regulate adhesion dynamics during migration. Recent advances in imaging technologies are allowing monitoring of these processes during migration and are providing insight into the mechanisms that regulate them.

MeSH Terms

Animals Biosensing Techniques Cell Adhesion/physiology Cell Cycle Proteins/metabolism Cell Movement/physiology Chick Embryo Cytoskeletal Proteins/metabolism Cytoskeleton/metabolism Drosophila Proteins/metabolism Extracellular Matrix/metabolism Fibroblasts/physiology Fluorescence Recovery After Photobleaching Focal Adhesion Protein-Tyrosine Kinases Focal Adhesions/physiology Guanine Nucleotide Exchange Factors/metabolism In Vitro Techniques Integrin alphaVbeta3/metabolism Microscopy, Fluorescence Paxillin Phosphoproteins/metabolism Protein Serine-Threonine Kinases/metabolism Protein-Tyrosine Kinases/metabolism Pseudopodia/metabolism Rho Guanine Nucleotide Exchange Factors Signal Transduction/physiology Vinculin/metabolism p21-Activated Kinases

Chemicals

Cell Cycle Proteins Cytoskeletal Proteins Drosophila Proteins Guanine Nucleotide Exchange Factors Integrin alphaVbeta3 Paxillin Phosphoproteins Rho Guanine Nucleotide Exchange Factors Vinculin Protein-Tyrosine Kinases Focal Adhesion Protein-Tyrosine Kinases Pak protein, Drosophila Protein Serine-Threonine Kinases p21-Activated Kinases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Webb Donna J

Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA. [email protected]

Brown Claire M

Horwitz Alan F

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(03)00105-4

[email protected]

Published

2003-10-00

Pages

614-20

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/s0955-0674(03)00105-4 View journal details

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